α -酮戊二酸在3种溶剂及其丙酮酸混合溶液中的溶解度测定及关联

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中图分类号：0645.1 文献标志码：A DOI：10.3969/j.issn.1003-9015.2025.01.006

Measurement and correlation of solubility of α -ketoglutarate in three solvents and their pyruvate mixed solutions

LI Xiaoting，CHEN Kui，HE Xiaochen，WU Bin，JI Lijun，WU Yanyang ：hool of Chemical Engineering，East China University of Scienceand Technology，Shanghai 2OO237，China

Abstract： The solubility of α -ketoglutarate（ α -KG）inwater，ethyl acetate（EA），n-butyl acetate（nBA）and pyruvate （PYR）under normal pressure was determined by a static method. Efects of PYR on the solubility of α 1 KGinwater，EA and nBA was studied.The results show that the solubility of α -KGinwater-PYR，EA-PYRand nBA-PYR is positively correlated with temperature.In water-PYR mixture solvents，the solubility of α -KG decreases with the increase of the molar ratio of pyruvate （y1）. In the EA-PYR and nBA-PYR mixed solvents，the solubility decreases firstandthen increases with theincreaseof the molarratioofPYR，and theminimumvaluesare near y2=0.60 and y3=0.47 ，respectively. Apelblat model， Yaws model and （CNIBS）/Redlich-Kister equation correlate well with the solubility data of α -KG in the three mixed solvents. The Thermodynamic parameters（ ΔsolHm'，ΔsolSm' and ΔsolGm ）of α -KG in above three systems were calculated by modified van't Hoff equation.

Key words ： α -ketoglutarate；pyruvate；solubility；thermodynamic fitting

1前言

（2号 α -酮戊二酸（ α -ketoglutarate）分子式为 C5H6O5 ，常温常压下为白色结晶。（剩余12278字）