水环境中G蛋白偶联受体药物的污染及生态毒性研究进展

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中图分类号：X131.2 文献标志码：A DOI:10.3969/j.issn.1003-9015.2025.01.001

Research progress of pollution and ecotoxicity of G protein-coupled receptor-acting pharmaceuticals in aquatic environment

LIU Ruipeng， ZHANG Han (School of Environmental Science and Technology，Dalian Universityof Technology，Dalian)

Abstract：The increasing attention tomicropolutants including pharmaceuticals in the environment is driven byadvancements in analytical techniquesand thepotential environmental risks.G protein-coupled receptor（GPCR）account for 40% ofpharmaceutical targets.There are around 7OO GPCR-acting pharmaceuticalswith large consumptions.Wastewater treatment plants are unable to completely remove GPCR-acting pharmaceuticals from sewage，which leadstotheir eventualrelease into aquatic environmentand posing potentialrisks to aquatic organisms.However，only limited GPCR-acting pharmaceuticalsare investigated inthe aquatic environment,andtheir ecological risksto aquaticorganisms remain largely unknown.This review provides a summaryof recent studies on GPCR-acting pharmaceuticals，analyzing their main sources，migration and transformation，methods for analysis and detectio of GPCR-acting pharmaceuticals in the environment，pollution and ecotoxicity，and ofers prospects for future research.

Key words:GPCR-acting pharmaceuticals；aquatic environment；migrationand transformation；polution；ecotoxicity

1前言

我国是药物生产大国，国家统计局数据显示，过去20年间我国化学原料药产量增长了近4倍，2023全年我国化学品原药产量达到 394.9×104 t。（剩余32373字）