NaErF4 基近红外二区纳米发光材料的生物应用进展
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关键词：NaErF4；近红外二区；下转移发射；荧光成像；成像引导治疗中图分类号：0482.31 文献标识码：ADOI：10.37188/CJL.20250062 CSTR：32170.14.CJL.20250062
RecentAdvancesinBiologicalApplicationsofNaErF -based NIR-I LuminescentNanomaterials
DENGHaozhong1，²，WANGWang'，CHEN Haoran1，CHANG Yulei1* （1.StateKeyLboratoryofuminescenceScienceandTechnology，ChangchunInstituteofOptics，FineMechanicsandPhysics， Chinese Academy of Sciences，Changchun 130o33，China; 2.UniversityofChineseAcademyofSciences，Beijing1Ooo49，China） *CorrespondingAuthor，E-mail：yuleichang@ciomp.ac.cn
Abstract：Compared to thevisibleand near-infrared-I（NIR-I）spectralregions，the near-infrared-I（NIR-I， 1000-170Onm）window has emergedasapromising frontier in bioimaging duetoits greatertisue penetration depth and reduced spontaneous background fluorescence.In recent years，significant progress has been made in applyingE r3+ -rich systems（NaErF4） as NIR-II fluorescent probes in biomedical photonics.These studies notonly focus on enhancing imaging signal-to-noise ratios and detectionsensitivity but alsoaim to achieveprecision imagingguided therapy fortumor regions.This review systematically summarizes the design strategies，luminescence mechanisms，andrecentadvances inthe biologicalapplicationsofNaErF4-basedNIR-Iluminescent nanomaterials.Additionally，the challengesassociated with their future translation are discussed.
Key words：NaErF4；NIR-I ；downshifting emission; fluorescent imaging；imaging-guided therapy
1引言
在医学成像技术领域，与核磁共振成像（MRI）、计算机断层扫描（CT）、正电子发射断层扫描（PET）和单光子发射断层扫描（SPECT）等传统成像技术相比，荧光成像技术因其无电离辐射风险、成本低以及时空分辨率高等优势，在生物诊疗研究中展现出巨大的潜力。（剩余27442字）
