近红外二区发光探针及生物成像

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中图分类号：0482.31 文献标识码：A DOI： 10.37188/CJL.20250130 CSTR：32170.14.CJL.20250130

NIR- I Luminescent Probes for Bioimaging

DUPing，YANG Xiaohan，XIAO He，SUN Lingdong

（BeijingNationalLaboratoryforMoleularSciences，StateKeyLaboratoryofRareEarthMaterialsChemistryandApplications， PKU-HKUJointLaboratoryinRareEarthMaterialsandBinoganicChemistry，CollegeofChemistryandMolecularEngineering， PekingUniversity，Beijing1O0871，China） *CorrespondingAuthor，E-mail：sun@pku.edu.cn

Abstract：Optical imaging inthesecondnear-infraredwindow（NIR-II，1Ooo-2OOnm）significantlyimproves in vivo imaging depth and resolution by reducing tissue scatering and autofluorescence.Over the past decade，the developmentof diverseNIR-II probesandimaging setupshasenabledNIR-IIimaging toovercomethe penetration depth limitations of conventional optical techniques，achieving cross-scale dynamic observation from macroscopic anatomical structures to microscopic molecular events，therebyproviding revolutionary toolsforbiomedicalresearch. This review systematicallysummarizes recentadvances inthedesignofNIR-Iluminescent probesandtheirbiomedical applications.The optical propertiesof various NIR-II probes are discussed，with a focus on their innovative applications in anatomical structure imaging，precision tumor diagnosis and therapy，real-time tracking of molecular events in vivo，responsive imaging，microenvironmentvisualization，and the constructionof integrated theranostic platforms.Finally，critical summaries and perspectives on the development and applications of NIR-I luminescent materialsarepresented，highlightingtheirpotentialforbroaderimpacts infundamentalresearchandclinical translation.

Key Words：optical imaging；second near-infrared window（NIR-II）；luminescent probes

1引言

活体成像技术作为生物医学研究的重要工具，在疾病诊断、手术指导、疗效监测等领域被广泛应用。（剩余29798字）