基于镧系发光纳米材料的神经影像与调控
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中图分类号：0482.31 文献标识码：ADOI：10.37188/CJL.20250046 CSTR：32170.14.CJL.20250046
Lanthanide-basedLuminescentNanoparticlesfor Neuroimagingand Neural Modulation
CHENJian，CHENFeixiang，XING Zhenyu，LIUYanyan （StateKeyLaboratoryofMolecular Engineeringof Polymers，ColegeofSmart MaterialsandFutureEnergy， FudanUniversity，Shanghai20oo82，China） * CorrespondingAuthor，E-mail：liuyyan@fudan.edu.cn
Abstract：Neuroscience research，central to both the International Brain Initiativeand China’s brain science strategy，seeks tounravelthecomplexitiesof thebrainandadress neurologicaldisorders，with technological innovation atitscore.Keytoadvancing this field isthedevelopmentof non-invasive imagingtechniques withhighspatiotemporalresolutionand precise，controlable neural modulation methods.Traditional imaging modalities，such as MRIand CT，areconstrainedbylimitations in biological safety，resolution，andtisue penetration.In paralel，external field modulationtechniques-basedonmechanical，thermal，acoustic，andmagneticprinciples—arehinderedbyisufficient spatiotemporal resolution and slow response times.Recently，near-infrared light has emerged as apromising tool in brain science due to itssuperiortissue penetrationand minimal phototoxicity.Among these，lanthanide-based luminescentnanoparticles standoutaskeyagents fornear-infraredlight-driventechnologies，capableofemiting tunableultraviolet，visible，andnear-infraredlightuponnear-infraredexcitation.Thesenanoparticleshavefound widespread applications inbiomedical detection，precise diagnostics，and intraoperativenavigation.This reviewprovides acomprehensive summaryof the latest advancements in theuse of lanthanide-based luminescent nanoparticles for neuroimagingand neural modulation，identifies existing technologicalchalenges，and explores future directions from theperspectivesof materials science，chemistry，andbiomedicine.Thereviewaims to foster interdisciplinary integration，stimulate technological innovation，and inspire breakthroughs in cuting-edge brainscience，offering newapproachesand strategiesforaddressingmajorchallengesinlife sciences.
Key Words：lanthanide-based luminescent nanoparticles；bioimaging；neural modulation
1引言
脑部疾病由于其特殊的病变部位、复杂的发病机制和高死亡率，已成为全球面临的重大挑战之一l。（剩余35239字）
