左侧星状神经节白细胞介素-6慢性过表达对心脏电生理的影响及机制探讨

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Effects of Chronic Overexpression of Interleukin-6 in Left Stellate Ganglion on Cardiac Electrophysiology and Investigation of Mechanisms

SHI Xiaoyu，JIANG Hong，YU Lilei

（Department of Cardiology，Renmin Hospital of Wuhan University，Cardiovascular Research Institute of Wuhan University， Hubei Key Laboratoryof Cardiology，Cardiac Autonomic Nervous System Research Center of Wuhan University，Wuhan 430060，Hubei，China）

【Abstract】ObjectiveToexaminetheeffectsandunderlyingmechanismsofchonicoverexpresionoftheinflammatorycytokine interleukin-6（L-6）ineftstellteanglio（SG）onardacltropsiologicalpropertis.MetosSitenhealtyeagswe randomly assgned to two groups：the IL-6 group （ n=8 ）and the control group （ n=8 ）. In the IL-6 group，multisite microinjections of AAV-IL6wereadministerdtoteSGhileteontrolgouceivedanqualvoueofli.Priortoectio，erumsamplseted， andLSGactivitywasmeasured.A24-hourambulatoryelectrocardiogammoitoringasperfoedbothpreoperativelyandonpostopative3 days，includingdecoilas（V）teal，tealspsindQspesiin colected，ndLctiviyseasdosugeryiGsetedfolealssulsAte significantiesdtoosodacalaesoeelels， or LSG activity.After 30 days of IL-6overexpression，the IL-6 group exhibited a significantly higher incidence of VA（ P<0.05 ），along with a marked reductioninbothQTand QTc intervals（ P<0.05 ），aswell asincreased dispersion of both the QT and QTc intervals（ P<0. 05 ）. Additionally，theI-6opsowdsignifcantlyevatedseuoepinerinlvelsndSGactivityomparedteontolgoupi notable increase in synaptophysin density in the LSG（ P<0. 05 ）.ConclusionChronic overexpression of IL-6 in the LSG compromises cardiacelectropsiologicaltabilitydisteincdenceofVAlikelyuetLGemodelig-induceddisruptiofdacutoc regulation.

【Keywords】 Interleukin-6;Left stellate ganglion;Autonomic nervous system

心脏自主神经系统由交感神经系统和副交感神经系统组成，这两个系统通过互相协调，以调节心肌能量代谢、心律以及血压等重要功能[]。（剩余7956字）