程序性细胞死亡在心肌纤维化中的研究进展

打开文本图片集

【中图分类号】R542.2+3 【文献标志码】A

Research advances in programmed cell death mechanisms underlying myocardial fibrosis

QiTingting'，ZhangXin²，Bai Li3 ，MaWen²，MaWenxiul

（1.Baotou Medical Collge，Inner Mongolia UniversityofScienceand Technology;2.Departmentof Cardiology，

The First Afliated Hospital of Baotou Medical Collge，Inner Mongolia Universityof Science and Technology; 3.The Central Lab，The First Afliated Hospital of Baotou Medical College，Inner Mongolia Universityof Science and Technology）

【AbstractThepathogenesisandprogresionofmyocardialfibrosis（MF）are modulatedbydiversecytokinesandsignalingpathways. Studiesinrecentyearshaverevealedanextremelycloseasociationbetween MFevolutionandprogrammedcelldeath（PCD）modalities，includingoosistogytosis，sisosisduprotosis.sticlevstactesif anddistinctPCDmodalities，ithparticularmphasisoncuting-edgediscoveries elucidatingPCDinthefieldofMF，hoping topro vide a theoretical-level reference basis for the in-depth exploration and clinical intervention of MF.

【Keywords】myocardial fibrosis;programmed cell death;research advances

心肌纤维化（myocardialfibrosis，MF）是多种心血管疾病进展中的关键病理机制，以心脏成纤维细胞（cardiacfibro-blasts，CFs）活化及细胞外基质（extracellularmatrix，ECM）过度沉积为特征，最终导致心脏结构重塑。（剩余25023字）