线粒体在代谢性疾病性别差异中的机制研究

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中图分类号R329.2 【文献标志码】A

Mechanism of mitochondria in gender differences of metabolic diseases

Zhou Xiangning，Yu Jingjing，Gao Ling

（Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging，Ministry of Education; DepartmentofEndocrinologyShandong Provincial Hospital Affiliatedto ShandongFirstMedical University） 【AbstractAsadualhubofenergy metabolismandsignaltransduction，mitochondria maintain metabolichomeostasisofthebodyby regulating intracellarATproduction，metabolicsignaltransduction，andintertissecommunicationnetworkndmocorial dysfunctionisoneoftheimportantriskfactorsformetabolicdiseases.Althoughprevioustudieshaverevealedtherelationshipbetween mitochondrialdsfunctionand metabolicdiseases，thespecificmchanismofactionrmainsunclearspeciallythe mechanismof genderdiffrencsintochondrialfunctionAtpresnt，telobalincdeneatesofetaboeateddseass，suchaseurodtivediseases，ardiovasculardiseasesandabnoral glucosemetabolism，ontinuetoiseandsowsignificantgenderdiferencs.ex hormonesestablishthemolecularbasisforgenderdiferencesinmitochondrialfunctionbyregulatingmitochondrialoxidatiephosphorylationefiencyalsigalingomestasisndoidntstressapacityuchenerdierecsofoalctiiy andfunctionmayonsituteanimportantbiologicalbasisforgendediferenesinmetabolicdiseass.Thisarticlesystematiclye viewsthebiologicalfunctionsofitochondriaandtheirpathologicalassociationswithmetabolicdiseases，focusingonteulatory mechanismofsexhrmone-mitchondrialinteractionetworkingenderdiferenesinmetabolicdiseases，inodertoprovideath retical basis for developing gender-specific preventionand treatment strategies.

【Keywordsmitochondria;strogen;neurodegenerativediseases;ardovasculardiseases;abnoralglucosemetabolismdisease;en der differences

线粒体起源于真核祖细胞吞噬的 ∝ 变形杆菌。（剩余16980字）