脂筏与糖尿病发生发展的最新研究进展

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【中图分类号】R335+9

【文献标志码】A

Recent advances in the role of lipid rafts in the development and progression of diabetes

Yang Lingkun，Jiang Jiawang，Zhang Mengyu，Gao Xiyue，Peng Shuhong

（Research Centerfor Diferentiationand DevelopmentofTCM Basic Theory，Jiangxi Universityof Chinese Medicine/ Key Laboratory of Traditional Chinese Medicine Etiology and Pathogenesis in Jiangxi Province） 【AbstractLipidaftseicrodomisiecellmbranethataeivoledinelligaltasductoetabolis，ndte larinteractions.Irecntyears，studieshaveshonthatipidraftsplayanimportantroleinthepathogenesisofdabetes.Colesterol andsphingolipidsarethainlpidomponentsinlipidafts，ndteproteincomponentsinlipidaftsiludecaveoliflotili，almitoylatedproteisndglyosylphosphtidylisitolanchordproteis.Cangsinsecomponentsfecttestucturedfucti oflipidraftsichiactisuiialrasucti，adigtoeouenceofabeteelateddiseass.Liidfse closelyrelatedtoteocueeaddvelopetofdabeesindifntissus.Pancreaticlipdaftsareloelyelatedtosuli cretion，ndteirstructuralcangesectinsulinsthesisandelease.Cangesinlipidaftsindiposetissueaerelatedtoisulin resistanceanddisordersofglycolipidmetabolism.Changesinlipidraftsintelivercanafectgluconeogenesisandglycogensythsis. Lipidrafts inthekidneyplyaregulatoryoleintheprogesioofdabeticnephopathyTisarticleitoprovideacomprhsive overviewoftholeoflidafsinethogensisofabetesfegisightstoidentificationofewgetsforhtio andtreatmentofdabetesinthefuture，aswellaspresentinganeperspectivefortedevelopmentoftherapeticagentsfordiabetes.

【Key words】diabetes;lipid rafts;pancreas;liver;adipose tissue

脂筏的概念在1997年由RegenSL1提出，用来描述细胞膜上富含糖鞘脂和胆固醇的新型微结构域。（剩余19949字）