高尔基体蛋白73在原发性胆汁性胆管炎中的临床价值探讨

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【中图分类号】R575.2 【文献标志码】A

【AbstractObjective：ToinvestigatetheroleofGolgiprotein73（GP3）inthediagnosisofprimarybiliarycholangitis（PBC）andits asociation withdiseaseprogresionandtherapeuticeficacymonitoring.Methods：Srumsamples werecollctedfrom70PBC patients，36patientswithliverdiseasesotherthanautoimmuneliverdisease（non-AILDgroup），and40healthycontrols（HCgroup）and ELISA wasusedtomeasuretheserumlevelofGP73.Forthinpatients withPBC，serumsampleswerecollctedbeforeandaftertreatmenttomeasureGP73.Results：TherewasasignificantdiferenceinthedistributionofserumGP73concentrationbetweenthePBC group，the non-AILD group，and the HC group（ P <0.001），and the receiver operating characteristic（ROC）curve showed that GP73 hadanarea undertheROCcurveofO.839 inthediagosisofPBC.Serum GP73level was positivelycorelated withaspartateaminotransferase（AST）（r=O.337，P=O.009），alkaline phosphatase（ALP）（r=0.380， P =0.003），totalbilirubin（r=0.330， P =0.010），and direct bilirubin（r=0.371， P =0.004），whileitwasnegatively correlated with prothrombinactivity（ r= -0.329，P =0.036）and cholinesterase（ r= T 0.518，P<0.001 ）.ThePBC patients with liver cirrhosishadasignificantlyhigherserumGP73levelthanthosewithoutlivercirhosis （ P=0.002 ）.Therewas nosignificantdiferenceinGP73contentbetweenthepatientswithpositiveanti-mitochondrialantibodies-M2， anti-BCOADC-E2PDC-E2OGDC-E2antibodies，andanti-SPloOantibodiesandthose withnegativeantibodies.ThePBC patients hadsignificantreductiosintheserumlevelsofAST，ALP，amagutayltranspeptidaseandGP73afterlive-protectingeatmet and improvement in cholestasis（ P<0.05 ）.Conclusion：GP73 playsan important role in the diagnosis，disease progression，and fficacy monitoring of PBC and is expectedto become a potential disease markerforPBC.

【Key words】Golgi protein 73;primary biliary cholangitis; diagnosis ;efficacy

高尔基体蛋白73（golgi protein 73，GP73）是存在于高尔基体上的一种Ⅱ型跨膜糖蛋白，主要由上皮细胞分泌，在正常生理状态下人体肝脏细胞基本不分泌GP73，血清GP73呈现低表达状态-2]。（剩余8202字）