依达拉奉右醇对脑出血大鼠的神经保护作用
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【中图分类号】R743.34 【文献标志码】A
【AbstractObjective：Toinvestigatetheroleandposiblemechanismofedaravonedexborneolinthepreventionandcontrolfpatho logicalinjuryofbraintissearoundhematomaafterintracerebralhemorhage（ICH）.Methods：Atotalof176Sprague-Dawleyrats wererandomlydividedintosham-operationgroup，ICHgroup，edaravone group，ndedaravonedexboreolgroup，with44rats ineach group.Allrats excepttoseintheshamoperationgroupwereusedtoestablisharatmodelofacuteICH，andach groupwasfurtherdivided into1-day，3-day， 7 -day，and14-day subgroups according to the time of evaluation，with1lrats in each subgroup.At2 hours aftermodeling，rugsweredministeedviaitraprioalijection，i，6ml/kgoalalinforthesamoperationgroudt ICH group，6 mg/kg edaravone for the edaravone group，and 7.5mg/kg edaravone dexborneol for the edaravone dexborneol group，followedbysubsequentadministrationevery12hoursuntilday14.Themodified NeurologicalSeverityScore（mNSS）wasusedtoassess neurologicalfunction;thewet-dryweightmethodwasusedtomeasurethewatercontentofbrain issue;thebiochemicalmethods were usedtomeasurenitricoxide（NO）andtotalantioxidantcapacity（T-AOC）inraintissearoundthehematoma;immunohistochemistry was used to measure the content of CD16 and CD2O6 in brain tissue around thehematoma.Results：ThemNSS scoreonday3（peakof the disease）was 0.6±0.5 for the sham-operation group， 14.0±1.6 （204 for the ICH group， 9.8±0.8 for the edaravone group，and 10.4±1.1 （204 fortheedaravonedexborneol group，with awater content of 63.2± 2.14，85.61± 1.43，81.48± 1.9，and 76.77±1.44 ，respectively，and the content of NO was 2.45±0.46 ， 9.98±0.54 ， 8.77±0.36 ，and （204号 7.92±0.43 ，respectively;the content of T-AOC was 0.67±0.02，0.74±0.03，0.78±0.02 ，and 0.84±0.03 ，respectively;the content of CD16 was 143.8±15.82 ，3 673.81±166.33 ，2 970.74±132.75 ，and 2 521.69±140.74 ，respectively；the content of CD206 was 548.46± 93.68，726± 97.81，915.28± 100.33，and 1119.51±160.52 ，respectively. Therewere significant differences in these indicators between the edaravone dexborneol group and the other three groups （all P<0.05 ）.Conclusion：Edaravone dexborneol can alleviate neurologicaldeficitcausedbyICHandexertaneuroprotectiveefectbyeducingbraintissueedemaroundthehematomaleviating oxidative stress，and regulating the polarization of microglial cells.
【Keywordsledaravonedexborneol;edaravone;intracerebralhemorrhage;oxidative stress;microglialcellpolarization
脑出血（intracerebralhemorrhage，ICH）在脑卒中各亚型中的发病率位居第二，死亡病例高达30%～40% ，治疗预后并不理想2。（剩余9156字）
