糖尿病与颅内动脉瘤形成及破裂相关性研究进展

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【中图分类号】R743 【文献标志码】A

【AbstractIntracranalaneurym（IA）isanabnoaltumor-likeprotrusinofintracranialblodvesselsandhasarelativelyhighincidencerate，anditsrupturecanleadtosignificantlypoorprognosis.Diabetes melitus（DM）isacommonchronicdiseasecaracter izedbyprolongedelevationofbloodglucoselevel，hichadverselyafectsthealthofpatients.Studieshaveconfirmedthepactf long-termhyperglycemiaonvscularhalthandfragilebodvesselsareanimportantprerequisitefortheonsetofaneuryms.hre fore，thepatients withDMmayhaveahigherincidencerateofaneurysms thanthose withoutDM.However，some studieshaveyielded conflictingresults.ClarifyingthemechanismsbywhichDMpromotestheformationofIAandleads tosubarachnoidhemorhageafter rupturemayhelptoprovideratinalandindividualizedtreatmentforDMpatientsupontheidentificationofaneurysmsandmprove their prognosis.This article reviews the impactofDMonthe formation and ruptureofIAandrelated risk factors.

【Key wordslintracranial aneurysm;diabetes mellitus;pathogenesis;association;review

颅内动脉瘤（intracranialaneurysm，IA）是局部血管壁损伤和变性，在血流动力学压力和其他因素的作用下，血管壁向外异常膨出形成。（剩余16949字）