弥漫大B细胞淋巴瘤患者血清白细胞介素17及白细胞介素35的表达及临床意义
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Expressionand clinical significance of IL-17and IL-35 in patients with diffuse large B-cellymphoma LinYuanfeng'，WenXiaofangl，LiuHuimei'，FangXiaoli'，HuangYiqun 'Departmentof ClinicalLaboratory，ZhangzhouHospitalAfliatedtoFujian Medical University，Zhangzhou363000，
China;²DepartmentofHematology，Zhangzhou HospitalAfiliatedtoFujianMedicalUniversity，Zhangzhou363000， China
【Abstract】ObjectiveTo explore thecorrelation between thechanges of serum IL-17and IL-35 levels in patients with DLBCL and the development，clinical data，treatmentplan and therapeutic effect of DLBCL，so as to provideanew theoretical basis for the diagnosis，treatment and prognosisassessment of DLBCL.Methods Screening a total of 62 patientswith DLBCL diagnosed bypathological and immunohistochemical examinations in theZhangzhouHospitalafiliatedofFujianMedicalUniversityfromJanuary2O21toJanuary2O24 wereincludedin the study group.40 healthy volunteers from the same period were selected as thecontrol group.The expressionlevels of IL-17and IL-35 were detected byELISA.ResultsThe serum IL-17levelof DLBCL patients was lower than thatof control group，but IL-35level was higherthanthatof thecontrol group.Serum levelsofIL-17and IL-35 in DLBCL patients werecorrelated with the Ann-Arbor stages，IL-17 was negatively corelated with the stage（r=-0.79， （204 P <0.05），but IL-35 was positively（r=0.71， P<0.05 ）. After treatment with RCHOP and CHOP in DLBCL patients，the increase of IL-17 and the decrease of IL-35 in RCHOP group were more significant than those in CHOP group. ConclusionThere are abnormal IL-17and IL-35 levels in DLBCL patients.RCHOP is more effctive than CHOP in increasing IL-17anddecreasing IL-35levels inserumof DLBCL patients.ThelevelsofIL-17andIL-35inserum of DLBCL patientsarecorrelatedwiththeprognosis.ThehigherlevelofIL-17andthelowerlevelofIL-35，thebetter prognosis of DLBCL patients.
【Key words】 Diffuse large B-cell lymphoma; Interleukin-17; Interleukin-35
DOI：10.19522/j.cnki.1671-5098.2025.05.016
淋巴瘤作为一组起源于淋巴结或其余淋巴组织的恶性肿瘤，根据组织病理学特征和临床特点分为霍奇金淋巴瘤（Hodgkin'slymphoma，HL）和非霍奇金淋巴瘤（non-Hodgkinlymphoma，NHL）。（剩余8993字）