肺炎患者463例痰液细菌培养结果及耐药性研究

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Bacterial culture and drug resistance in sputum of 463 patientswith pneumonia

JiaDishun

DepartmentofClinicalLaboratory，hanxi HospitalofIntegratedTraditionaland WesternMedicine，TiyuanO30013，

China

【Abstract】 Objective To analyze the bacterial culture results and drug resistance of sputum in patients with pneumonia，and to provide referenceforclinical treatment.MethodsFrom April 2O22 toFebruary 2024，463 patients with pneumonia who receiveddiagnosis and treatmentin Shanxi Integrated Hospitalof Traditional Chinese and Western Medicine were included in this study.Allpatients underwent sputum bacterial culture，and the results of sputumbacterialculture and drug resistance were analyzed to layafoundation fortherationalityof antimicrobial application.ResultsThe sputum culture results of 463 patients with pneumonia showed thata total of 526 strains of pathogenic bacteriawere isolated，336strainsof gram-negativebacteriaand190 strainsof gram-positivebacteria. Among the gram-negative strains，Klebsiella pneumoniae accounted for the highest proportion of 14.8% （78 strains）， followed byMoraxella kataxella （12.9%） （68strains）. The highest proportion of gram-positive bacteria was Streptococcus pneumoniae （13.1 % ）（69 strains），followed by Staphylococcus aureus （11.4 % ）（60 strains）. The resistancerateof Klebsiella pneumoniae toerythromycin was the highest：92.8%，folowed by benzylpenicillin 91.3% . Thesensitivity rate to teicolanin，vancomycin and linezolid was the highest （ 100% ），followed byertapenem 98.6% and imipenem 97.1% .The resistance rate of Streptococcus pneumoniae to ampicillin was 100% . The sensitivity rate to ertapenem was the highest in 98.7% ，followed by amikacin and imipenem （96.2 % ）. Conclusion Streptococcus pneumoniae and Klebsiella pneumoniae are the main pathogens causing pneumonia patients，and the degreeofresistance to commonlyused clinical antibiotics is different.In the courseof treatment，appropriate antibacterial drugsshould be selected according to the actual situation to speeduptherecovery process of patients.

【Key Words】 Pneumonia;Sputum；Bacterial culture；Drug resistance DOI：10.19522/j.cnki.1671-5098.2025.05.015

肺炎是呼吸内科发病率较高的疾病类型，主要因病原体入侵肺部导致，各个年龄段均有可能发病。（剩余4688字）