联合检测血清抗苗勒管激素和维生素D表达水平 对多囊卵巢综合征患者妊娠结局的预测价值

打开文本图片集

XuJiao'，RaoHongyun²，ChenRul

'DepartmentofGynaecologyandObstetrics，thePeople'sHospitalofHebi，Hebi458O30，China;²Departmentof

ReproductiveMedicine，thePeople'sHospitalofHebi，Hebi458o3o，China

【Abstract】 Objective To explore the predictive value of serum anti-Mullerian hormone （AMH）and vitamin D（VD）levels for pregnancy outcomes in patientswith polycystic ovary syndrome （PCOS）.MethodsA retrospective analysis was conducted on10O cases of clinical data of PCOS patientsadmited to Hebi People's Hospital from March 2O22 to March 2024.Allpatients were treatedwithethinylestradioland cyproterone acetate combined with metformin，and clomiphene citrate was used for ovulation induction in the fourth menstrual cycle. The patients with good pregnancy outcomes （7O cases） were clasified as the good pregnancy outcome group，and those with poor pregnancy outcomes （30 cases）were classified as the adverse pregnancy outcome group.Another 50 non-PCOS women preparing for pregnancy during the same period were selected as the control group.General data， fetal prognosis，serum AMH，and 25-（OH）D levels of the three groups were compared，and the predictive value of AMH and 25-（OH）D alone and in combination was calculated.ResultsThe AMH levels in the good pregnancy outcome group and the adverse pregnancy outcome group were higher thanthose in the control group，while the 25- （OH）D levels were significantly lower than those in the control group （P<0.05） ）.Thereweresignificant differencesin the indicators between the good pregnancy outcome group and the adverse pregnancy outcome group （ P <0.05）. The age and BMI of the good pregnancy outcome group were lower than those of the adverse pregnancy outcome group （ P （20号 <0.05）.Multivariate Coxregressonanalysisshowed that high AMH levelsand low25-（OH）D levelswere independent risk factors for adverse pregnancy outcomes in PCOS patients （P

【Key Words】 Polycystic ovary syndrome;Anti-Mullerian hormone;Vitamin D; Pregnancy outcomeDOI：10.19522/j.cnki.1671-5098.2025.04.012

多囊卵巢综合征（polycystic ovary syndrome，PCOS）是一种常见内分泌疾病，多表现为高雄激素血症或卵巢多囊样改变，特征为持续无排卵或少排卵，是育龄女性不孕原因之二[1-2]。（剩余7270字）