核因子 -κB 白细胞介素-17及趋化因子受体1水平对哌拉西林/他唑巴坦治疗儿童社区获得性肺炎疗效的预测研究

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PredictionofNF- κκB ，IL-17and CXCR1levelsonthe efficacyof piperacillin/tazobactam in the treatmentof children with communityacquired pneumonia

WuXiaozhen，JiaJunfang，FengRuina

DepartmentofPediatricIntrenalMedicine，LinyingCountyMaternalandChildHealthCareHospital，Luohe462600，

China 【Abstract】 Objective To investigate the relationship between nuclear factor-KB（NF-kB），interleukin-17 （IL

-17）andchemokinereceptor1（CXCR1）ontheeffectsof piperacilln/tazobactamonchildrenwith communityacquired pneumonia.MethodsA total of 90 children who received piperacilin/tazobactam in the treatmentof CAP in Linying County Maternal and Child Health Hospital from January to December 2O23 were retrospectively selected，and divided into effective group （ n =66） and ineffective group （n=24） according to their efficacy.The clinical data and levels of NF-kB，IL-17 and CXCR1 before treatment were analyzed and compared between the two group. MultivariateLogisticregressionanalysis wasused toanalyze thefactorsaecting thetherapeuticeffectofchildren with CAP.Receiver operating characteristic （ROC） curves were used to evaluate the eficacy of NF-kB，IL-17，and CXCR1 alone and in combination to predict the eficacyof children receiving piperacilin/tazobactam for CAP. ResultsBeforetreatment，there were statisticallsignificantdiffrencesinNF-kB[（22.5±6.6）ng/Lus.（31.8±8.2）ng/ L， t： =5.570，P<0.001]，IL-17 （23.5±2.4 vs.27.2±2.4， t =6.539， P <0.001）， CXCR1[（54.2±11.2）pg/ml vs. （69.3±11.4）pg/ ml， t=5.616， P <0.001]， and age （ χ2 =11.080， P =0.004） between the two groups.NF-kB [OR（95%CI）=2.328（1.086， 4.990），P=0.030]，I-17[OR（95%CI）=5.691（1.206，0.796），P=0.017]，CXCR1[OR（95%CI）=5.691（1.314，7.063） 0.009] and age <3 years before treatment [OR（95%CI）=2.328（1.085，4.997），P=0.030] were independent factors affectingthe efcacyof children receiving piperacillin/tazobactam for CAP;thearea under theROC curve（AUC）of NF- κ B， IL-17，and CXCR1 before treatment were 0.804，0.862，0.830，and 0.977，respectively，for predicting the effcacyof piperacilin/tazobactam inchildren treated with CAP.ConclusionCombinedNF-kB，IL-17，and CXCR1 levels before treatment predict the eficacy of children receiving piperacilln/tazobactam for CAP.

【Key words】 Community acquired pneumonia; Children；Nuclear factor-KB; Interleukin-17； Chemokinereceptor 1

DOI：10.19522/j.cnki.1671-5098.2025.03.010

社区获得性肺炎（communityacquired pneumonia，CAP）主要由细菌、病毒及支原体等多种感染所致，是我国5岁以下儿童主要致死的呼吸系统疾病之一[]。（剩余5020字）