穿刺液降钙素在甲状腺髓样癌中的诊断价值

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Diagnostic value ofcalcitoninintheaspiration fluid for medullarythyroidcarcinoma

ZhangLirong，YangMeiyu，ZhengDengzi，KeNantian，ChenZejin

DepartmentofClinicalLaboratory，theSecondAffiliatedHospitalofFujianUniversityofTraditionalChinese

Medicine，Fuzhou 350001，China

Corresponding author： Chen Zejin， Email： 185484765@qq.com

【Abstract】 Objective To explore the diagnostic value of calcitonin （CT）in the aspiration fluid for medullary thyroid carcinoma （MTC）.MethodsThedataof140patients whounderwentfine-needle aspirationbiopsy （FNAB） ofthyroidnodulesintheSecondAfiliated HospitalofFujian UniversityofTraditional ChineseMedicine from August2022 to July 2O24 were selected.Among them，30 patients pathologically diagnosed with MTC served as the MTC group. Meanwhile，55 patients with pathologically confirmed thyroid benign lesions during the same period were selectedas the benign control group，and 55 patients with papillary thyroid carcinoma（PTC）werechosen as the PTC control group.The calcitonin levels in the aspiration fluid of each group of patients were detected，and the correlations between them and the serum calcitonin levels as wellas the results of ultrasound，CTand other maging examinations were analyzed to explore the sensitivityand specificityof calcitonin in the aspiration fluid for the diagnosis of MTC.ResultsThe results showed that the calcitonin levels in the aspiration fluid of the MTC group were significantly higher than those of the benign control group and the PTC control group（ P <0.001），and therewas asignificant positive correlation between thecalcitoninlevels in theaspirationfluidand theserumcalcitonin levels （r=0.783， P<0.001 ）.Through testing，the sensitivity of the detection of calcitonin in the aspiration fluid for MTC reached 86.7% （26/30），the specificity was 96.4% （106/11O）. Conclusion This study indicates that the detection of calcitoninintheaspirationfluidisanefcientandaccuratediagnosticmethodforMTC.Itssensitivityand specificityare higherthanthoseof traditional diagnostic methods，anditissimple tooperateandcauses lesstrauma. It is expectedto become an important auxiliary means for the early diagnosis of medulary thyroid carcinoma.

【Key words】 Puncture examination; Calcitonin; Medullary thyroid carcinoma; Early diagnosisDOI：10.19522/j.cnki.1671-5098.2025.03.004

甲状腺癌是内分泌系统最常见的恶性肿瘤之一，其发病率呈现出逐年递增的态势，对人类健康构成了极为严重的威胁[1]。（剩余6119字）