系统性红斑狼疮患者补体3补体4及白细胞介素-17白细胞介素-22表达水平
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Expressionlevelsofcomplement3，complement4，cytokinesinterleukin-17and interleukin-22inpati-ents withsystemic lupuserythematosus
Geng Yingying，Li Shasha，Jia Shanshan，An Mengli
DepartmentofNephrologyRheumatologyandImmunology，theFirstPeople'sHospitalofhangqiuCityngqi
476100， China
【Abstract】Objective To analyze and study the expression levels of complement 3（C3），complement 4（C4）， and cytokines IL-17and IL-22 in patients with systemic lupus erythematosus （SLE）. MethodsThe study subjects were80 SLE patients who visitedour hospital from March 2O22 to March 2O24.Inaddition，8O healthy individuals who underwent health examinations atour hospital during the same period were selectedas the control group.All subjects underwent C3，C4，andcytokine IL-17，IL-22 testing upon admisson.The levels of various indicators were compared between SLE patients in theactiveand remission stagesand thecontrol group.ResultsThe levels of cytokines IL-17and IL-22 in active and remision phases of SLE patients were higher than those in the control group，and the levels of related indicators in active phase were higher than those in remission phase （ P <0.05）; The levels of C3 and C4 in active and remission phases of SLE patients were lower than those in thecontrol group，and the levels of related indicators in the active phase were lower than those in the remission phase （ P <0.05）. The levels of cytokines IL-17 and IL-22 in SLE patients were positively correlated with SLEDAI scores （ r= 0.525，0.483， P< （204 0.05），and negatively correlated with C3 and C4 levels （ r=. -0.487，-0.254，P<0.05）.Conclusion C3 and C4，as well as cytokines IL-17and IL-22，exhibitabnormal expresson levels inSLEpatientsandcanserveasimportant indicators for disease diagnosis and monitoring.
【Key Words】 Systemic lupus erythematosus; Complement 3; Complement 4; Interleukin-17; Interle-ukin-22
系统性红斑狼疮（systemic lupuserythematosus，SLE）是常见的一类自身免疫病，病情相对复杂，发病率较高，目前尚未完全明确其具体的发病机制，多认为与集体免疫系统被异常激活，攻击自身组织引发，另外也可能与遗传、环境及雌激素等因素相关[1]。（剩余5823字）