结直肠息肉危险因素的Meta分析

打开文本图片集

AbstractObjective：TosystematicallyevaluatetheriskfactorsforteoccuenceofcolorectalpolypsMethds：Acomputerzdsearh was conductedinCNKI，VIP，WanFangDatabase，CBM，PubMed，CochraneLibrary，andEMbaseDatabaseforstudiesontherisk factorsofcolorectalpolyps.ThesearchperiodspannedfromtheestablishmentofthedatabasestoJune2，2O25.Tworesearchers independentlyperformedliteraturescrening，qualityasessment，anddataextraction.Meta-analysiswasconductedusingReview Manager5.4softwareandEggerststsperfedusingStata8.0oftware.Results：Atotalof29sudieswereincludediolving 9 987 patients.The results of the meta-analysis showed that age[OR .=1.08 95% CI（1.06，1.11）]，male[OR ⟹1.63 ， 95% CI（1.43，1.85）]， smoking[OR ：=1.93 ， 95% CI（1.68，2.21）]，alcohol consumption[OR =1.58 ， 95% CI（1.36，1.83）]，abnormal triglycerides[OR =1.65 ， 95% CI（1.43，1.90）]，obesity[OR =1.67 ， 95% CI（1.31，2.12）]， fattyliver[OR=2.87， 95% CI（1.87，4.4O）]，diabetes[OR .=3.34 ， 95%CI （2.10，5.31）]，high-fat diet[OR .=3.27 ， 95% CI（2.24，4.78）]，helicobacter pylori infection[OR ∘eq 1.71，95%CI（1.38，2.13）]，abnormal uric acid[OR =1.57 ，95%CI（1.22，2.03）]，gallbladder disease[OR -1.78 ， 95% CI（1.43，2.23）]，family historyofcancer[OR =2.43 ， 95%CI （1.61，3.68）]，abnormal cholesterol[OR =1.92 ， 95% CI（1.39，2.65）]，waist circumference[OR 95% CI（1.04，2.8O）]，hyperlipidemia [OR =1.54 ， 95% CI（1.23，1.93）]，and family history of polyps[OR =8.27 ， 95% CI（2.22，3o.86）] were risk factors for the occurrence of colorectalpolyps.Conclusions：Therearemanyriskfactorsforcolorectalpolyps.Medical staffshouldenhanceawarenessofdisease screeningandprovidepersonalizedandpreciseinterventionthroughamultidisciplinaryintegrationmodelreducetheincidenceof precancerous polyps and alleviate the disease burden.

Keywords colorectal polyps;risk factors; precancerous polyps;Meta-analysis

结直肠癌（colorectalcancer，CRC）是全球最常见的癌症之一[1]。（剩余14064字）