基于孟德尔随机化分析11种微量元素和22种饮食与妊娠剧吐的因果关系

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AbstractObjective：Tovestigateteausalrelatioshipetwentraceementscalci，onincelenm，magese vitaminAi），cd cookedvegeabldifritollsdatbledd hotdrinks，carbonatedeverage，arlicitake，Cinesechie）andhyperemesisgravidarumusingMendelianndomzation.MetdsAll data were summarizedbyusig Genome-Wide Asociation Studies（GWAS），withsingle nucleotide polymorphisms（SNPs）as istrumental variables.Analyseswereperformedusinginversevarianceweighting，weightedmode，MREgerandweightedmedian.Cochrane'sQtest wasusedtoidentifyheterogeeityofresults.MREggerinterepttestand"leaveoeout"testwereapledtoevaluatetheobustssf theassociationsbetweenthe1traceelements，22detaryfactorsandhyperemesis gravdarum.Results：eresultssowedthatain D supplementation could reduce the risk of hyperemesis gravidarum[OR =0.48 95% CI（0.30，0.75）].No significant effects of the other10 trace elements or 22 dietary factors on the risk of hyperemesis gravidarum were observed P>0.05 ）.There was no horizontal pleiotropy or heterogeneity（ P>0.05） ，indicating the robustness oftheresults.Conclusions：Vitamin Dcould reduce the risk of hyperemesis gravidarum. Noeffectsoftheother1Otraceelementsodietaryfactorsonincreasingordecreasingtheiskofhyperemesisgravidarumwerefound temporarily.

Keywordstrace elements;diet; pregnancy;hyperemesis gravidarum; Mendelian randomization;causal inference

妊娠剧吐（hyperemesisgravidarum，HG）是一种妊娠代谢紊乱，表现为严重的恶心和呕吐，其定义为脱水、尿酮体增高和体重减轻 5% 以上。（剩余10903字）