软脉消斑汤治疗痰瘀互结型颈动脉粥样硬化易损斑块临床研究

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[中图分类号]R259；R543.5 [文献标志码］A [文章编号]0256-7415（2026）06-0091-07

DOl:10.13457/j.cnki.jncm.2026.06.015

Clinical Study on Ruanmai Xiaoban Decoction for Vulnerable Carotid Atherosclerotic Plaques of Phlegm Blended with Blood Stasis Type

ZHAO Na，LI Wei，WANG Yiru，WU Zhimin，ZHANG Lumi Wenzhou TCM Hospital of Zhejiang Chinese Medical University，Wenzhou Zhejiang 3250oo， China

Abstract：Objective：To observe the clinicaleficacy and safetyof Ruanmai Xiaoban Decoction in the treatment of vulnerablecarotidatheroscleroticplaquesof phlegm blendedwithbloodstasistype.Methods:Atotal of104 patients with vulnerable carotidatherosclerotic plaquesadmited toWenzhou Hospitalof Traditional Chinese Medicine from January to December 2O24 were selectedand randomly divided into the western medicine groupandthe combination group using the random number table method，with 52 cases ineach group．The western medicine group received Atorvastatin treatment，whilethecombination group received Ruanmai Xiaoban Decoction in addition to the treatment regimen of the western medicine group.Both groups were treated for12 weeks.Changes in plaques，blood lipids, hemorheology，aswell as clinical eficacy and safety were compared between the two groups.Results：After treatment，the intima-media thickness （IMT），total plaque thickness，total plaque area，traditional Chinese medicine syndrome score，low-density lipoprotein cholesterol（LDL-C），triglycerides（TG），total cholesterol（TC）, plasma viscosity，whole blood low-shear viscosity，and whole blood high-shear viscosity decreased inboth groups ( P0.05 ）. Conclusion：Ruanmai Xiaoban Decoction is effective in the treatmentof vulnerable carotid atherosclerotic plaques of phlegm blended with blood stasis type.It can stabilize plaques，improve traditional Chinese medicine symptoms, regulate blood lipids and hemorheology，and shows good safety.

Keywords:Carotid atherosclerotic plaque；Vulnerable plaque；Ruanmai Xiaoban Decoction；Phlegm blended with blood stasis；Low-density lipoprotein cholesterol；Hemorheology； Intima-media thickness；Plaque area

颈动脉粥样硬化(CAS)是心脑血管疾病的关键危险因素，随着时间的累积可引起颈动脉狭窄甚至堵塞，导致短暂性脑缺血发作和脑卒中等急危重症，威胁患者生命安全。（剩余12708字）