基于隐结构模型和关联规则分析慢性萎缩性胃炎用药规律

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[中图分类号]R256.3； ［文献标志码]A［文章编号]0256-7415（2026）06-0015-08

DOl:10.13457/j.cnki.jncm.2026.06.003

Analysis of Medication Patterns for Chronic Atrophic Gastritis Based on Latent Structure Model and Association Rules

ZHUPeiwen，LI Bo，ZHANG Guangyu，LIANG Zhitao HenanProvince Hospital of Traditional Chinese Medicine，Zhengzhou Henan 45OoO2，China

Abstract:Objective:To analyze the medication patterns of traditional Chinese medicine（TCM） in the treatment of chronic atrophic gastritis （CAG）based on alatent structure model combined with asociation rules，thus providing a theoretical basis for clinical CAG treatment.Methods:A systematic search was conducted in ChinaNational Knowledge Infrastructure（CNKI)，China Biology Medicine disc（CBM），VIP Information，and Wanfang Database for efective medical cases of CAG since theestablishment of the databasesup to March1，2025.After screening he literature，a database was established using Microsoft Excel，andlatent structure modelandasociation rules analyses were performed using Lantern 5.O and RStudio software.Results:A total of 134 articles were included，yielding 12 TCM syndrome types.The main TCM syndrome types were stomach collteral blood stasis syndrome (2 486 cases, （204号 27.14% ） and spleen deficiency syndrome (1 943 cases， 17.14% ). The analysis involved 190 Chinese herbal medicines , andthetop fivewiththe highestfrequency wereGlycyrrhizaeRadix etRhizoma，Atractylodis MacrocephalaeRhizoma, Poria，Codonopsis Radix，and Paeoniae Radix Alba. Herb properties were predominantly warm；herb flavors were mainly sweet，bitter，and pungent.The primary meridian tropisms were the spleen and liver meridians.In terms of fectcategories，herbs were mostlycategorizedas deficiency-tonifying，blood-activatingand stasis-resolving，and heat-clearing.Association rulesanalysis identified 2O stronglyassociated core herb pairs，with the highest support being Atractylodis Macrocephalae Rhizoma-Glycyrrhizae Radix et Rhizoma.Latent structure model analysis yielded six latent variables，four comprehensive clustering models，and nine core prescriptions.Conclusion:The nature of CAG ischaracterizedbydeficiency inoriginand excess insuperficiality.Weakness of spleenandstomach is the core pathogenesis.Clinical treatment should focus onregulating the spleen and stomach while ensuring the free movementof liverqi.Thetreatment mainlyinvolves tonifyingdeficiency，activating bloodandresolving stasis，andclearingheat. Prescription-based syndrome diferentiation mainly targets spleen (stomach）deficiency syndrome，liver-stomach qi stagnation syndrome，stomach yin deficiency syndrome，and stomach collateral blood stasis syndrome.

Keywords:Chronic atrophic gastritis；Association rules；Latent structure model；Medication patterns

慢性萎缩性胃炎(CAG)是临床常见的胃肠道疾病之一，其病理特征为胃壁上皮细胞持续受到攻击，部分腺体萎缩，可合并或不合并肠上皮化生(IM)和不典型增生(Dys)，一般认为是胃癌(GC)的癌前病变。（剩余12228字）