芪浙消瘦方联合硒酵母治疗气虚痰凝型桥本甲状腺炎合并良性甲状腺结节临床研究

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[关键词］桥本甲状腺炎；良性甲状腺结节；气虚痰凝证；芪浙消癭方；硒酵母；中医证候；炎症反应[中图分类号］R265；R581.4 ［文献标志码］A [文章编号]0256-7415（2026）06-0079-06DOI:10.13457/j.cnki.jncm.2026.06.013

Clinical Study on Qizhe Xiaoying Prescription Combined with Selenious Yeast for Hashimoto's Thyroiditis with Benign Thyroid Nodules of Qi Deficiency and Phlegm Coagulation Type

ZHONG Zuanyi, ZHOU Yuqing，WU Qianying Department of Endocrinology，Dongguan Traditional Chinese Medicine Hospital，Dongguan Guangdong 5230oo，China

Abstract:Objective:To observe the clinical efficacy of Qizhe Xiaoying Prescription combined with Selenious Yeast inthe treatment of Hashimoto's thyroiditis（HT）with benign thyroid nodulesofqi deficiencyand phlegm coagulationtype，and to investigate its effcton inflammatory responses.Methods:A totalof 66 patients with HTand benignthyroid nodulesofqi deficiencyand phlegmcoagulation type，treatedatDonggan Traditional Chinese Medicine Hospital from April 2023 to October 2024，were selected.They were randomly divided into the treatment group and the control group using the random number table method，with 33 cases in each group.During the study，1 case dropped out from the control group and1casewas excluded from the treatment group，resulting in 32 patients in each group completing the study.The control group was treated with Selenious Yeast Capsules，while the treatment group received Qizhe Xiaoying Prescription combined with Selenious Yeast Capsules.Both groups were treated for 12 weeks.Traditional Chinese medicine syndrome scores，levels of anti-thyroid peroxidase antibody（TPOAb）, anti-thyroglobulinantibody（TgAb），thyroid-stimulating hormone（TSH），freethyroxine（FT4），free triiodothyronine（FT3），interleukin-17（IL-17），interferon -γ (IFN- γ ），and interleukin-10（IL-10），as well as changes in thyroid isthmus thickness and the maximum diameterof thelargestnodule，were observed before and after treatmentinboth groups.The traditional Chinese medicine syndrome eficacyand the incidenceof adverse reactions were compared between the two groups.Results:After12 weeks of treatment，traditional Chinese medicine syndrome scores and levels of TPOAb，TgAb，IL-17，and IFN- γ in both groups decreased compared with those before treatment ( P0.05 ).There were no statistically significant differences in FT3，FT4，and TSH levels within each group before andafter treatment，nor between the two groupsafter 12 weeks ( P>0.05 ). The total effective rate for traditional Chinese medicine syndrome efficacy in the treatment group was 90.63% （29/32），higher than that of 65.63% （21/32）in the control group ( P0.05 ）．Conclusion:Qizhe Xiaoying Prescription combined with Selenious Yeastshows significant clinicalefcacyinthetreatmentofHTwithbenign thyroid nodulesofqi deficiencyand phlegm coagulation type. Its mechanism may involve alleviating the inflammatory responses.

Keywords:Hashimoto's thyroiditis；Benign thyroid nodule；Qi deficiency and phlegm coagulation syndrome; Qizhe Xiaoying Prescription； Selenious Yeast； Traditional Chinese medicine syndrome； Inflammatory responses

桥本甲状腺炎(HT)被广泛认定为一种器官特异性自身免疫性疾病，属于慢性淋巴细胞性甲状腺炎的一种。（剩余11695字）