活化通络方联合西药治疗症状性颅内动脉粥样硬化性狭窄临床研究

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[中图分类号]R277.7；R743.3 [文献标志码］A [文章编号]0256-7415（2026）06-0066-07

DOl:10.13457/j.cnki.jncm.2026.06.011

Clinical Study on Huohua Tongluo Prescription Combined with Western Medicine for Symptomatic Intracranial Atherosclerotic Stenosis

ZHANG Junting，WANG Yonghui，JIANG Lingxiu Departmentof Neurology，TheFirstAfiliated Hospitalof Henan University，Kaifeng Henan 4750oO，China

Abstract:Objective:To observe the clinical eficacy of Huohua Tongluo Prescription combined with western medicine in treating symptomatic intracranial atheroscleroticstenosis （sICAS）of qi deficiencyand blood stasis type. Methods:Atotal of98patients with sICASofqi deficiencyand blood stasis type admitted to The FirstAfiliated Hospitalof Henan University from October 2O22 toFebruary 2O24wereselectedandrandomly divided intoan observation group and acontrol group using a random number table method，with 49 cases in each group.Both groups receivedconventional symptomatic treatment，including Aspirin Enteric-Coated Tabletsand Clopidogrel Bisulfate Tablets.The observation groupadditionally received Huohua Tongluo Prescription．Both groups were treated for three months.Before and after treatment，intracranial arterial hemodynamic parameters [peak systolic velocity（Vs），mean velocity（Vm），pulsatilityindex（PI)]，cerebrovascular reactivity index [breath-holding index（BHI)]，serum concentrationsof Tau proteinand visinin-like protein-1（VILIP-1）were measured.National Institutes of Health Stroke Scale（NIHSS） scores，modified Rankin Scale （mRS） scores，and Montreal Cognitive Assessment （MoCA） scores were assessed.Clinical effcacy，incidence of adverse reactions，and recurrence rate were compared between the two groups.Results:After treatment，thetotal effectiverate in the observation group was higherthan that inthe control group ( P0.05 ).The recurrence rate in the observation group was lower than that in the control group ( P

Keywords：Symptomatic intracranial atherosclerotic stenosis；Qi deficiencyand blood stasis syndrome；Huohua Tongluo Prescription；Cerebral hemodynamics；Cerebrovascular reactivity；Cognitive function

症状性颅内动脉粥样硬化性狭窄(sICAS)是缺血性脑卒中的重要致病因素，其风险与狭窄数量、狭窄程度呈正相关。（剩余14203字）