微小RNA-1976在细胞周期异常疾病中的研究进展

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关键词：微小RNA-1976；异常细胞周期；癌症；中枢神经系统疾病中图分类号：R362 文献标识码：A 文章编号：1000-503X（2025）04-0644-07DOI：10.3881/j. issn.1000-503X.16376

Advancesin the Studies ofMicroRNA-1976 in Aberrant Cell Cycle Diseases

JI Haoyu’，CHEN Hao’，SHI Liang²，ZHANG Meng¹，CHEN Ting'，KONG Yingming’，FENG Rongke 1 DepartmentofNeurology，Third HospitalofShanxi Medical UniversityShanxiBethuneHospital，ShanxiAcademyofMedicalSciences， Tongji Shanxi Hospital，Taiyuan O3Oo32，China 2 Departmentof HistologyandEmbryology，Schoolof Basic Medicine，Shanxi MedicalUniversity，Jinzhong，Shanxi O30619，China

Corresponding author：CHENHaoTel：0351-2170933，E-mail：1403352675@qq.com

ABSTRACT： Most tumor cellsand healthy neurons are at rest during GO phase. Once the cell cycle is abnormally re-entered under certain conditions，the proliferation of tumorcellsand the degenerative necrosis of neurons can be initiated.From the perspective of the cellcycle，cancer and central nervous system diseases，two seeminglydiffrent disease types，have a common pathogenesis.This typeof diseases is namedaberrant cellcycle diseases.Asanewlydiscovered microRNA（miR），miR-1976 is closelyrelated to theregulationof thecellcycle. This review summarizes the progress in the research on miR-1976 in cancer and central nervous system diseases， aiming to provide areference for the clinical application of miR-1976 in aberrntcell cycle diseases in the future.

Key words：microRNA-1976；aberrant cell cycle；cancer；central nervous system disease

ActaAcadMedSin，2025，47（4）：644-650

细胞周期是细胞从静止状态（G0期）到分裂完成的有序过程，主要分为G1期（DNA合成前期）、S期（DNA复制期）、G2期（DNA合成后期）和M期（有丝分裂期）。（剩余17566字）