去乙酰化酶3在脓毒症相关疾病中的功能和调控作用研究进展

关键词：去乙酰化酶3；脓毒症；多器官功能障碍

中图分类号：R631 文献标识码：A 文章编号：1000-503X（2025）04-0601-10

DOI：10.3881/j.issn.1000-503X.16371

Research Progress in the Function and Regulation of Sirtuin 3 in Sepsis-Related Diseases

LI Junjie’，MEI Hong²，LIU Xinxin'，YU Kun1 ，FENG Banghai²，FU Bao¹，QIN Songl 1 Departmentof Critical Care Medicine，Affliated Hospitalof Zunyi Medical University，Zunyi，Guizhou 5630oo，China （20 2 Department of Critical Care Medicine，Zunyi Traditional Chinese Medicine Hospital，Zunyi，Guizhou 5630o0，China

Corresponding author：QIN Song Tel：0851-28609875，E-mail：120647053@qq.com

ABSTRACT： Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection，with a high mortality rate.Sirtuin 3，a deacetylase within mitochondria，plays an important regulatory role in celular metabolism，oxidative stress，and inflammatory responses.In recent years，significant progress has been made in the study of the function and regulatory role of sirtuin 3 in sepsis-related diseases.Research has shown that sirtuin 3 can aleviate organ damage caused by sepsis by regulating mitochondrial function，reducing oxidative stress，and inhibiting inflammatory responses.The specific mechanisms include the regulation of mitochondrial bioenergetics，activation of antioxidant enzymesystems，and inhibition of inflammatorymediator expression.In addition，sirtuin 3 plays a protectiverole in the pathological process of sepsis by interacting with multiple signaling pathways.This article summarizes thefunctions andregulatory mechanisms of sirtuin 3 in various sepsis-related diseases，aiming to provide new targets and strategies forthe prevention and treatment of sepsis in the future.

Key words：sirtuin 3；sepsis；multiple organ dysfunction

ActaAcadMedSin，2025，47（4）：601-610

脓毒症是由感染引起的危及生命的器官功能障碍，治疗主要依赖于液体复苏和抗感染措施，但其高发病率和死亡率仍未得到有效控制。（剩余29568字）