双麟酸盐影响种植体稳定性的动物及临床研究新进展

关键词：双麟酸盐；种植体；骨结合；药物相关性颌骨坏死

中图分类号：R783.4 文献标识码：A 文章编号：1000-503X（2025）04-0628-06

DOI：10.3881/j.issn.1000-503X.16365

Progress in Animal and Clinical Studies on the Impact of Bisphosphonates on Implant Stability

JIA Linglu1.23.4，GONG Zikai23.4.5， ZHAO Wenxi 2，3，4，5 ， WEN Yong2..4.5

1 Departmentof Prosthodontics，Scholand Hospital of Stomatology，Cheeloo Collgeof Medicine，Shandong University， Jinan ，China 2 Shandong Key Laboratory of Oral Tissue Regeneration，Jinan ，China （20 3 Shandong Engineering Research Center of Dental Materialsand Oral Tisse Regeneration，Jinan 25Oo12，China （204 4 Shandong Provincial Clinical Research Center for Oral Diseases， Jinan 25Oo12，China

（20 5 Department of Implantology，School and Hospital of Stomatology，Cheeloo Collgeof Medicine，Shandong University， Jinan ，China

Correspondingauthor：WENYong Tel：O531-88382595，E-mail：wenyong@sdu.edu.cn

ABSTRACT：Bisphosphonates（BP），a class of commonly used medications for treating osteoporosis and bone malignancies，significantly affect bone metabolism. When dental implants are placed in patients receiving BP，the potential impacts of BPonthe formation and long-term maintenanceof implant osseointegration cannot be ignored.In addition，the influence of dental implants onthe occurrence of BP-related osteonecrosis of the jaw is garnering attention.This article explores the influences of BPon the stabilityof dental implants based ona review of previous animal and clinical studies，discusses the impact of dental implants on the occurrence of BP-related osteonecrosis of the jaw，and proposes suggestions for the dental implant treatment of patients taking

BP in clinical practice.This review is expected to providea theoretical basis forthe related research and clinical treatment.

KeyWords：bisphosphonates；implants；osseointegration；medication-related osteonecrosis of the jaw

ActaAcadMedSin，2025，47（4）：628-633

双麟酸盐（bisphosphonates，BP）是一类抗骨吸收药，对骨代谢有显著影响，目前被广泛用于治疗骨质疏松症、骨恶性肿瘤等疾病。（剩余14756字）