六分钟步行试验对急性高山病的预测价值

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关键词：急性高山病； 6min 步行试验；LakeLouise评分 中图分类号：R448 文献标识码：A 文章编号：1000-503X（2025）04-0535-07 DOI：10.3881/j.issn.1000-503X.16373

Value of 6-Minute Walking Test in Predicting Acute Mountain Sickness

JIANG Yufan1，²，MA Qiang³，CHEN Haiwei³，HAN Baoshi³，FENG Bin³，CHEN Yundai 1，3 1 Department of Cardiology，The First Medical Center，Chinese PLA General Hospital，Beijing 10o853，China （204号 2 Department of Cardiology，Fujian Cardiovascular Medicine Center，Fujian Medical University Union Hospital， Fuzhou 350001，China （204 3 Department of Cardiology，The Sixth Medical Center，Chinese PLA General Hospital，Beijing 100048，China

Correspondingauthor：CHEN Yundai Tel：18610530521，E-mail：cyundai@vip.163.com

ABSTRACT： Objective To evaluate the value of pre-ascent 6-minute walking test performed at a high altitude in predicting the incidence of acute mountain sickness （AMS）induced byrapid ascent to a very high altitude.MethodsAfter baseline information was colected，participants completed the 6-minute walking test at a high altitude of 2900m .Then，they rapidly ascended to a very high altitude of 5 OoO m. The Lake Louise score was recorded to asess AMS.ResultsThe AMS group showed a shorter pre- ascent 6-minute walking distance （6MWD）at the high altitude than the non-AMS group [480.0O （450.00，521.75）m vs.546.00 （516.50， 568.50）m， P=0.006 ].No difference was observed regarding the pre-ascent heart rate or peripheral oxygen saturation（both P>0.05 ）.The pre-ascent 6MWD at the high altitude was negatively correlated with the Lake

Louise score assessed after rapid ascent to the very high altitude （ r=-0.497 ， P=0.012 ）. Logistic regression analysis confirmed that the pre-ascent 6MWD atthe high altitude was associated with the risk of AMS induced by rapid ascent to the very high altitude （ OR=0.971 ， 95% CI=0.947-0.996 ， P=0.022 ）.The results indicated that the pre-ascent 6MWD demonstrated ideal prediction performance（area under receiver operating characteristic curve =0 .846， P=0.006 ）.ConclusionThe pre-ascent 6MWD recorded at thehigh altitude is a convenient and reliable predictor of the AMS induced by rapid ascent to the very high altitude.

Keywords：acute mountain sickness；6-minute walking test；Lake Louise scori

ActaAcadMedSin，2025，47（4）：535-541

随着人类对高海拔地区等极端环境的探索，人们将面对比以往更多的特殊事件和突发事件。（剩余13337字）