新型冠状病毒感染患者康复一年后血浆的非靶向代谢组学

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关键词：严重急性呼吸综合征冠状病毒2；新型冠状病毒感染；非靶向代谢组学；康复 中图分类号：R34 文献标识码：A文章编号：1000-503X（2025）04-0519-08 DOI：10.3881/j. issn. 1000-503X.16347

Untargeted Metabolomics of Plasma From Coronavirus Disease 2O19 Patients One Year After Recovery

ZHANG Xutong，YANG Yehong，WU Yue， HAN Rong，WANG Qiaochu，DING Tao，LIU Jiangfeng，YANG Juntao

State KeyLaboratory of Common Mechanism Researchfor Major Diseases，Department of BiochemistryandMolecular Biology， Instituteof BasicMedicalSciences，CAMSandPUMC，Beijing1OOoO5，China

Corresponding author：YANGJuntao Tel：18610762155，E-mail：yangjt@pumc.edu.cl

ABSTRACT： ObjectiveTo investigate the recovery of plasma metabolism in asymptomatic and mild patients of coronavirus disease 2O19（COVID-19） one year after recovery.MethodsA total of 174 participants were recruited from the communities in Wuhan，including 8O healthy volunters and the COVID-19 patients who had recovered for one year. According to the disease severity，the recovered COVID-19 patients were grouped as asymptomatic patients（ n=80 ）and mild patients（ n=14 ）.The liquid chromatography mass spectrometry platform was employed to study the metabolomic characteristics of the plasma from all the participants. Results The plasma metabolites in asymptomatic patientsand mild patients remained abnormal compared with those in healthy volunteers.Among the diferential metabolites in asymptomatic patientsand mild patients，some metabolites showed a downward trend only in mild patients，such as phosphatidylethanolamine[ 20：3 （5Z，8Z， 11Z） /P-18：0⋅ ]，sphingomyelin （ d18：1/24：0 ），and cholesteryl （ 15：0 ）.The metabolic pathway involving the diferential metabolites in mild patients was mainly glycerophospholipid metabolism. ConclusionsEven one year after recovery，the mild COVID-19 patients still exhibit metabolic abnormalities.Hence，these patients may experience an extended period of time for recovery.

Keywords：severe acute respiratory syndrome coronavirus 2；coronavirus disease 2O19；untargeted metabolomics；recovery Acta Acad Med Sin，2025，47（4） ：519-526

严重急性呼吸综合征冠状病毒2（severeacutere-spiratory syndromecoronavirus2，SARS-CoV-2）这一正链RNA病毒引起全球公共卫生危机，导致新型冠状病毒感染（coronavirusdisease2019，COVID-19）的出现[1]。（剩余10329字）