噬菌体对肿瘤的影响机制及其治疗作用的研究进展

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中图分类号：R730.5文献标识码：A 文章编号：1000-503X（2025）03-0470-08

DOI：10.3881/j.issn.1000-503X.16282

Advances in Influencing Mechanisms and Therapeutic Effects of Bacteriophages on Cancer

XIAO Yuyang，MA Yuyang， ZHANG Yibo，CHEN Cheng，MENG Yang， ZHAO Mingyi

DepartmentofPediatrics，The Third Xiangya HospitalofCentral South University，Changsha41OO13，China

Corresponding author：ZHAO Mingyi Tel：17773135083，E-mail：zhao_mingyi@csu.edu.cn

ABSTRACT：Cancer brings about an enormous threat to human health，making the exploration of its mechanisms and therapeutic strategies a current focal point and chalenge in research. Bacteriophages are integral components of the human microbiome，and studies have shown their influences on tumor growth and metastasis and their pivotal roleincancer treatment.Thisarticleelucidates the mechanisms bywhich bacteriophages impact the occurence and development of cancer from their interactions with cancer cells，effcts on bacteria，and influence on the immune system.Additionally，it explores bacteriophage-based strategies in cancer treatment andtheir potential inthis field.Thisarticleaims tobring newthoughtsand insights to theresearch inthis field.

Key words：bacteriophage；cancer；bacteriophage-bacterium interaction；bacteriophage therapy

ActaAcadMedSin，2025，47（3）：470-477

癌症是全球公共卫生领域面临的主要威胁之一，对人类健康与社会经济发展造成严重的负面影响[1]对癌症发生发展机制及其预防、诊断和治疗的探究一直是医学研究的热点。（剩余22004字）