胃食管反流病与慢性阻塞性肺疾病发病风险的关系

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中图分类号：R563.9；R573.9 文献标识码：A 文章编号：1000-503X（2025）03-0402-06

DOI： 10.3881/j .issn.1000-503X.16279

Association Between Gastroesophageal Reflux Disease and the Risk of Incident Chronic Obstructive Pulmonary Disease

LIAO Ye 1 ，ZHOU Yunfeng²，ZHOU Xiaorui¹，HU Xin³，LIAO Juan4，LONGLu1

1 DepartmentofEpidemiologyandHealthStatistics，²Deparmentsof Thoracic Surgery，WestChinaScholofPublic Healthand West China Fourth Hospital，Sichuan University，Chengdu 61OO41，China （20 3 Shiyang Community Health Service Center，Chengdu Hi-Tech Zone，Chengdu 610041，China

（204号 4 Department of Gastroenterology，West China Scholof Public Health and West China Fourth Hospital，Sichuan University， Chengdu 610041，China

Corresponding author：LONG Lu Tel：028-85501272，E-mail：longlu201609@163.com

ABSTRACT： ObjectiveTo investigate the association between gastroesophageal reflux disease （GERD） and the risk of incident chronic obstructive pulmonary disease（COPD）and explore potential effect modifiers influencing this asociation.MethodsClinical data from 476175 participants in the UK Biobank （2006-2010） were collected.A Cox proportional hazards model was used to assess the relationship between GERD and the risk of incident COPD.Subgroup analyses were conducted to examine potential modifiers of the primary findings. Results A total of 11 587（ 2.43% ）new COPD cases were diagnosed. The Cox proportional hazards model revealed that GERD was associated with an increased risk of incident COPD（ HR=1.59 ， 95% CI= 1.46 - 1.74， P<0.001 ）. GERD was linked to a higher risk of incident COPD in individuals aged <60 years（ P< 0.001）and non-smokers（ P=0.011 ）.No association was observed between GERD and the risk of incident

COPD in current smokers with a daily cigarette consumption <10 cigarettes （ P=0.261 ） . Conclusion GERD mayincrease the risk of incident COPD.

Key Words：gastroesophageal reflux disease；chronic obstructive pulmonary disease；prospective study ActaAcadMedSin，2025，47（3）：402-407

2019年全球 30～79 岁人群中慢性阻塞性肺疾病（chronic obstructivepulmonary disease，COPD）的患病率约为 10.3% ，随着人口老龄化、城市化及其相关风险的增加，COPD逐渐成为全球死亡的主要原因[1]。（剩余9752字）