脑内多巴胺能系统在全身麻醉中作用的研究进展

中图分类号：R614 文献标识码：A 文章编号：1000-503X（2025）03-0441-06

DOI：10.3881/j. issn.1000-503X.16245

Research Advancements in the Role of the Brain Dopaminergic System in General Anesthesia

LUO Wei 1，2 ，YUAN Chengdong1，²，HAO Mengnan1，²， ZHANG Jie’， ZHANG Yi 1，2

（20 1 Department ofAnesthesiology，The Second Afiliated Hospitalof Zunyi Medical University，Zunyi，Guizhou 5630，China 2 KeyLaboratoryofAnesthesiaandOrganProtectionofGuizhouProvince，ZunyiMedical University，Zunyi，Guizhou5630oo，China

Corresponding author：ZHANGYi Tel：15329716676，E-mail：chersishher1998@126.com

ABSTRACT：General anesthesia is widely used in clinical practice，whereas the exact mechanism behind thegeneral anesthetic-induced reversible loss of consciousness remains unclear.Recent studies have revealeda close relationship between the dopaminergic system and general anesthetic-induced lossof consciousness.This system，encompassing dopamine neurons，dopamine receptors，and related neural pathways，regulates functions such as movement，memory，arousal，and cognition.The dopaminergic neurons in the ventral periaqueductal gray and ventral tegmental area，along with D1 receptors，have been shown to facilitate emergence from anesthesia.However，theroleof D2receptors remains controversial.Thisreview summarizes recentadvancementsinthe roleof the dopaminergic system in general anesthesia and theunderlying mechanism，with the aim of clarifying he mechanism of general anesthesia and providing atheoretical basis forpreventing delayed emergence fromanesthesia.

Key words：dopaminergic system；general anesthesia；dopamine neuron；neural pathway；dopamine receptor ActaAcadMedSin，2025，47（3）：441-446

全身麻醉是一种由麻醉药物诱导的可逆性状态，包括意识消失、顺行遗忘、镇痛和肌肉松弛[1]。（剩余14741字）