光声成像在甲状腺癌精准诊疗中的研究进展

中图分类号：R445.1文献标识码：A 文章编号：1000-503X（2025）03-0447-05

DOI：10.3881/j. issn. 1000-503X.16349

Research Progress of Photoacoustic Imaging in the Precision Diagnosis and Treatment of Thyroid Carcinoma

MA Jiaojiao 1，2，3 ，XI Xuehua1，²，DU Yang4，5， ZHANG Bo 1，2，3

1 Department of Ultrasound，China-Japan Friendship Hospital，Beijing 1Ooo29，China 2 National Center for Respiratory Medicine，National Clinical Research Center for Respiratory Diseases ， Institute of Respiratory Medicine of ChineseAcademy of Medical Sciences，Beijing 1OoO29，China （204号 3 Chinese Academy of Medical Sciencesand Peking Union Medical Colege，Beijing 100730，China （204 4 CAS Key Laboratory of Molecular Imaging，Instute of Automation， Chinese Academyof Sciencs，Beijing 100190，China （204 > University of Chinese Academy of Sciences，Beijing 10o080，China

Corresponding author：DU YangTel：O10-82618465，E-mail：yang. du@ia.ac.cn; ZHANG Bo Tel：010-84205417，E-mail：thyroidus@163.com

ABSTRACT： The incidence of thyroid cancer keeps rising globally，with the majority being papillary thyroid carcinoma （PTC），which has a favorable prognosis. However，some aggressive PTCs exhibit diferent clinical behaviors and higher mortalityrisks，with thegrowthrate surpassing thatof well-differentiated PTCandundiferentiated cancers.Therefore，achieving precise diagnosis and treatment of thyroid carcinoma presents a significantchalenge.Photoacoustic imaging is a molecular imaging technologythat integrates optical imaging andultrasound，providing imaging information on structure， function，and molecules. Moreover， it can utilize exogenous contrast agents to realize tumor treatment，such as photothermal therapy，serving as a promising technologyfor precise diagnosisand treatment of thyroid carcinoma.Researchers both domesticallyand internationally have explored the application of photoacoustic imaging in the precise diagnosis and treatment of thyroid tumors.This article reviews the research progress，elucidates the advantages and limitations of photoacoustic imaging in thediagnosisand treatment of thyroid carcinoma，and prospectson the precise diagnosis and treatment of this disease.

Key words：thyroid carcinoma；photoacoustic imaging；precision diagnosis and treatment；molecular imaging ActaAcadMed Sin，2025，47（3） ：447-451

甲状腺癌是内分泌系统最常见的恶性肿瘤，发病率呈逐年递增趋势[1-3]，早期诊断和精准治疗是降低其死亡率的关键。（剩余10259字）