骨朗格汉斯组织细胞增生症八例并文献复习

病例报告

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关键词：骨朗格汉斯组织细胞增生症；诊断；治疗；免疫组织化学

中图分类号：R365；R738.1 文献标识码：B 文章编号：1000-503X（2025）02-0325-08

DOI：10.3881/j.issn.1000-503X.16077

Langerhans Cell Histiocytosis of Bone： Report of Eight Cases and Review of the Literature

BI Ya，WU Dandan，YU Fangying，FANG Zhenhong，HUANG Bo

DepartmentofRespiratoryndCriticalCareMedicine，AflitedHospitalofZunyiMedicalUniversity，Zunyi，Guizhou5630，China

Corresponding author：HUANG Bo Tel：0851-28609032，E-mail：13985229382@139.com

ABSTRACT：Langerhans cell histiocytosis of bone is a rare tumor disease characterized by the large accumulation of CD1a+ and CD207 + dendritic cells in tissues of unknown cause. It mainly occurs in children aged 1-4 years old，with incidences of4-6 per million in children and1-2 per million inadults.Due to its low incidence， diverse clinical manifestations，and noobvious specificityof imaging manifestations，the definitive diagnosis and early treatment of this type of tumor are challenging. In this paper，we report8 cases ofLangerhans cellhistiocytosis of boneand review therelevantliterature published inthe past five years to summarizethe clinical characteristics，pathological features，diagnosis，treatment，and prognosis of this disease.

Key words：Langerhans cell histiocytosis of bone；diagnosis；treatment； immunohistochemistry

Acta Acad Med Sin，2025，47（2）：325-332

朗格汉斯组织细胞增生症（Langerhanscellhistio-cytosis，LCH）是一种以朗格汉斯细胞增生为特征的一组病变实体，是一种介于良、恶性之间的组织细胞增殖性疾病[1]。（剩余13927字）