运动发挥抗炎作用改善神经炎症相关抑郁症的研究进展

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关键词：运动；抑郁症；神经炎症；抗炎；运动处方

中图分类号：R749.4；G807.4文献标识码：A 文章编号：1000-503X（2025）02-0191-07

DOI：10.3881/j. issn.1000-503X.15991

Research Progress in the Anti-Inflammatory Effect of Exercise in Ameliorating Neuroinflammation- Related Depression

ZHANG Zhixin1，²，GUO Qi1，CHEN Xiaoyu Colegeof Rehebilitation Sciences，Shanghai Universityof Medicineand Health Sciences，Shanghai 2O1318，China Tianjin Key Laboratoryof Exercise Physiologyand Sports Medicine，Institute of Sport，Exercise and Health， TianjinUniversityofSport，Tianjin，China

Corresponding author：CHEN Xiaoyu Tel：18822202275，E-mail：1334427886@qq.com

ABSTRACT：Depression is an affective disorder caused by multiple factors，and its pathogenesis is stil unclear.However，in recent years， studies have found an association between neuroinflammation and depression， which is mainlyreflected inthe interaction of their pathogeneses，such as abnormalitiesof monoamine neurotransmiters inthe brain，dysregulation of thehypothalamic-pituitary-adrenal axis，anddysfunction of neurogenesis. Currently，exerciseas a therapy for depression has attracted widespread attntion. By reviewing relevant research reports，this article summarizes that exercise allviates neuroinflammation by playing an anti-inflammatory role， thus improving the mood-related pathway to treat depresion.Furthermore，thisarticle explores theefects of different exercise prescriptions on the anti-inflammatory role of exercise，aiming to provide new scientific ideas for the treatment of depression associated with neuroinflammation.

Key words：exercise；depression；neuroinflammation；anti-inflammatory；exercise prescription

ActaAcadMedSin，2025，47（2）：191-197

抑郁症是一种最常见的精神疾病，以情绪低落、快感缺失和社交障碍等表现为主。（剩余19111字）