高同型半胱氨酸血症与慢性肾脏病关系的研究进展

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关键词：慢性肾脏病；同型半胱氨酸；高同型半胱氨酸血症；叶酸；维生素中图分类号：R589.9文献标识码：A 文章编号：1000-503X（2025）02-0281-08DOI：10. 3881/j. issn.1000-503X.16112

Research Progress in the Relationship Between Hyperhomocysteinemia and Chronic Kidney Disease

DING Congcong ，HUANG Xiao ，BAO Huihui ，CHENG Xiaoshu

Department ofCardiovascular Medicine，The Second Afiliated Hospitalof Nanchang University，Nanchang 330o06，China （204号 Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center，Nanchang 330o6，China Jiangxi Sub-Center of National Clinical Research Center for Cardiovascular Diseases，Nanchang 33oo06，China

（20 Center for Preventionand Treatment ofCardiovascular Diseases，The Second Afliated Hospitalof Nanchang University， Nanchang 330006，China

Corresponding author：CHENG Xiaoshu Tel：0791-86268844，E-mail：xiaoshumenfan126@163.com

ABSTRACT：In patients with chronic kidney disease（CKD），the incidence of cardiovascular events and the mortality rate are significantly higher than those in the general population. Approximately 8 5 % of end-stage CKD patients develop hyperhomocysteinemia （HHcy）due to impaired renal function.It is notyet full determined whether HHcy merely acts asa biomarker of CKD or plays arole in the pathogenesis.Although supplementation with folic acid and other B vitamins （B6 and B12）has been proven to lower the plasma level of total homocysteine，their effectiveness in slowing CKD progresion or reducing cardiovascular complications remains uncertain.This article reviews the latest research progress in the relationship between HHcyand CKD，aiming to give new insights into the prevention and treatment of CKD and its complications.

Key Words：chronic kidney disease；homocysteine；hyperhomocysteinemia；folic acid；vitamin

ActaAcadMedSin，2025，47（2）：281-288

慢性肾脏病（chronickidneydisease，CKD）是导致心血管疾病（cardiovasculardiseases，CVD）的重要原因之一，给全球带来了沉重的经济和健康负担。（剩余18858字）