辜酮在男性抑郁症中的作用研究进展

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通信作者：陈小雨电话：021-65883301，电子邮件：1334427886@qq.com

关键词：睾酮；抑郁症；睾酮替代治疗；性腺功能减退症；雄激素剥夺治疗 中图分类号：R588；R749文献标识码：A 文章编号：1000-503X（2025）02-0274-07 DOI： 10.3881/j. issn. 1000-503X.16142

Research Progressin the Role of Testosterone in Male Depression

FU Jiamin’，GUO ， CHEN Xiaoyu²

College of Sportsand Health，Tianjin Universityof Sport，Tianjin 30160，China （20 College f Rehabilitation Sciences，Shanghai Universityof Medicineand Health Sciences，Shanghai2Oo93，China

Corresponding author：CHEN Xiaoyu Tel：021-65883301，E-mail：1334427886@qq.com

ABSTRACT： As the social pressure is increasing， the incidence of depression is growing. Testosterone is synthesizedand secreted through the hypothalamic-pituitary-gonadal axis，which plays aregulatory role in men's mental health.Studieshave shownthat low testosterone levels，clinical hypogonadism，and androgen deprivation therapy-induced testosterone deficiencyaresignificantly associatedwith male depression，while therearestill many uncertainties about the mechanism of their effects. Given that low testosterone levels may serve as a characteristic biomarker of male depression risk，testosterone replacement therapy may have a good therapeutic effect on maledepression.This article focuses onassessing therole of testosterone levelsand related clinical therapies in mood regulation in men.

Key words：testosterone;depresson;testosterone replacement therapy； hypogonadism；androgen deprivation therapyActaAcadMedSin，2025，47（2）：274-280

抑郁症是全球最大的健康挑战之一，它影响着全球超过3亿人，并导致生活质量下降、残疾和过早死亡[1]。（剩余17155字）