辜酮在男性抑郁症中的作用研究进展

打开文本图片集
通信作者:陈小雨电话:021-65883301,电子邮件:1334427886@qq.com
关键词:睾酮;抑郁症;睾酮替代治疗;性腺功能减退症;雄激素剥夺治疗 中图分类号:R588;R749文献标识码:A 文章编号:1000-503X(2025)02-0274-07 DOI: 10.3881/j. issn. 1000-503X.16142
Research Progressin the Role of Testosterone in Male Depression
FU Jiamin’,GUO , CHEN Xiaoyu²
College of Sportsand Health,Tianjin Universityof Sport,Tianjin 30160,China (20 College f Rehabilitation Sciences,Shanghai Universityof Medicineand Health Sciences,Shanghai2Oo93,China
Corresponding author:CHEN Xiaoyu Tel:021-65883301,E-mail:1334427886@qq.com
ABSTRACT: As the social pressure is increasing, the incidence of depression is growing. Testosterone is synthesizedand secreted through the hypothalamic-pituitary-gonadal axis,which plays aregulatory role in men's mental health.Studieshave shownthat low testosterone levels,clinical hypogonadism,and androgen deprivation therapy-induced testosterone deficiencyaresignificantly associatedwith male depression,while therearestill many uncertainties about the mechanism of their effects. Given that low testosterone levels may serve as a characteristic biomarker of male depression risk,testosterone replacement therapy may have a good therapeutic effect on maledepression.This article focuses onassessing therole of testosterone levelsand related clinical therapies in mood regulation in men.
Key words:testosterone;depresson;testosterone replacement therapy; hypogonadism;androgen deprivation therapyActaAcadMedSin,2025,47(2):274-280
抑郁症是全球最大的健康挑战之一,它影响着全球超过3亿人,并导致生活质量下降、残疾和过早死亡[1]。(剩余17155字)