P糖蛋白在不同组织器官中的定位和调控研究进展

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关键词：P糖蛋白；分子结构；转运机制；定位；调控 中图分类号：Q71文献标识码：A 文章编号：1000-503X（2025）02-0295-08 DOI：10.3881/j. issn.1000-503X.16156

Advances in the Localization and Regulation of P- glycoprotein in Different Tissues and Organs

ZHAO Jiahua¹²，YANG Xiaosa²，XU Xiaojiao1²，LIU Rui'，²，ZHUANG Tiantian ， ZHANG Jiatang'

（204号 School of Medicine，Nankai University，Tianjin 300071，China （204号 DepartmentofNeurology，TheFirstMedical Center，ChinesePLAGeneralHospital，Beijing100853，China （20 Graduate School，Medical School of Chinese PLA，Beijing 100853，China Corresponding author：ZHANG JiatangTel：010-55499321，E-mail：zjt1128@aliyun.com

ABSTRACT：P-glycoprotein（P-gp）is an ATP-dependent efflux transporter that is distributed in many tissues and organs.P-gp can selectively pump endogenous substrates and exogenous chemicals from the cellto the outside of the cellto maintain a stable endo-environment.However，it meanwhile restricts the entry of therapeutic drug into tissues and organs，and in particular，mediates the multidrug resistance of tumor cels to chemotherapeutic drugs.Therefore，understanding the localization of P-gp in diferent tissues and organs maybe an important breakthrough point for disease treatment.In this paper，we mainly review the molecular structure，transport mechanism，localization，and regulation of P-gp in diferent tisses and organs，providing reference forthe subsequent treatment of diseases.

Key Words：P-glycoprotein；molecular structure；transport mechanism； localization；regulation

ActaAcadMedSin，2025，47（2）：295-302

细胞毒性抗癌药物成功应用于癌症治疗的同时，也带来了药物不良反应和患者因多药耐药（multidrugresistance，MDR）而导致治疗失败的挑战[1]。（剩余20368字）