自主神经调节策略在心肌梗死治疗中的研究进展

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中图分类号：R541.7 文献标识码：A 文章编号：1000-503X（2025）02-0309-05

DOI：10.3881/j. issn. 1000-503X.16150

Research Progress of Autonomic Nerve Regulation in the Treatment of Myocardial Infarction

LI Shanshan’，XIONG Mengting1，GUO Miaomiao² （204号 Cardiac Function Examination Room， Department of Pharmacy，Jingmen People'sHospital，Central Hospital Afiliated to Jingchu Universityof Technology，Jingmen，Hubei 4480Oo，China

Corresponding author：GUO Miaomiao Tel：0724-6903039，E-mail：602618950@qq.com

ABSTRACT： The autonomic nervous system imbalance caused by the overactivation of the sympathetic nerveand the weakenedactivityof the parasympathetic nerve is closelyrelated to the occurrence and development of myocardial infarction. Autonomic nerve regulation is a new therapeutic approach aiming at inhibiting sympathetic activityand increasing parasympathetic activity.It encompasses magnetic nerve stimulation，optogenetic neuromodulation，and microinjectionof botulinum toxin，which could promote the rebalance of the autonomic nervous system，thereby curbing the deterioration of the cardiac function and reducing the occurrence of ventricular arrhythmias after myocardial infarction.This paper reviews the anatomical basis，mechanisms of action，and research advances in intervention strategies of the autonomic nervous system in myocardial infarction.

Key Words：autonomic nerve；myocardial infarction；ventricular arrhythmia；vagus nerv

ActaAcadMedSin，2025，47（2）：309-313

急性心肌梗死（acutemyocardialinfarction，AMI）作为常见的心血管急危重症之一，具有难治愈、致残率及死亡率高等特点[1]。（剩余12888字）