中药活性成分及复方通过NF-kB通路干预脓毒症相关性急性肾损伤的作用机制

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中图分类号R965；R285 文献标志码A 文章编号 1001-0408（2025）21-2747-06

DOI 10.6039/j.issn.1001-0408.2025.21.23

ABSTRACTSepsis-asociatedacute Kidney injury（SA-AKI） isanacute kidneyinjurycausedbysepsis，characterized byacute onset，severe progression and high mortality.The abnormal activation of the nuclear factor- ∇×B （NF- σκB ）signaling pathway can lead topathological procesessuchasrenalinflammatorycascadereactions，oxidativestress，apoptosisandpyroptosis，and microcirculatorydysfunction，thereby promotingthedevelopmentofSA-AKI.Inrecent years，thebasicresearchontheprevention andtreatment of SA-AKI with traditional Chinese medicine（TCM） has made significant progress，among which NF- κB plays an importantroleasakeyfactor.Thisarticlesummarizestheresearchfindingsoverthepastfewyearsonactiveingredientsand compound formula of TCM interventions for SA-AKI via the NF- κB signaling pathway. It elaborates on various active ingredients ofTCM，suchasflavonoids，phenols，glycosides，terpenoids，quinonesandalkaloids，aswellasTCMcompoundformulations including Qihuang jiedu huayudecoction，Huangqijiuni decoction，andXuebijing ijection，etc.Theseinterventionssignificantly inhibitrenal inflammatoryresponses，oxidativestress，apoptosis，pyroptosisandmicrocirculatorydysfunctionbyregulating multiple NF- κB mediated signaling pathways，such as Toll-ike receptor 4/myeloid differentiation primaryresponse protein 88/NFκB ，sirtuin 1/NF- κB ，NF- κB/ NOD-like receptor family pyrin domain-containing protein 3，thereby alleviating SA-AKI and improving renal function.

KEYWORDSsepsis；acute kidney injury;nuclear factor- ⋅κB ； traditional Chinese medicine；active ingredients；compound formula

脓毒症是指机体对感染产生的炎症反应失调所引起的危及生命的器官功能障碍。（剩余16187字）