雷公藤及其活性成分对免疫球蛋白A肾病的作用机制研究进展

中图分类号R965；R285 文献标志码A 文章编号 1001-0408（2025）21-2742-05

DOI 10.6039/j.issn.1001-0408.2025.21.22

ABSTRACTImmunoglobulin Anephropathy（IgAN）isacommon primaryglomerulardiseaseanda frequent causeof chronic renalfailure.TripterygiumwilfordiisatraditionalChineseherbalmedicine，whichpossesestheeffectsofpromotingblood circulation，relievingswelingandpain，anddispelingwindanddampness.Moderpharmacologicalstudieshaveshownhat T. （204号 wilfordiimultiglucosideexhibitanti-inflammatoryandimmunomodulatoryects，inibitmesangialcellproliferation，protect podocytes，ameliorateendothelialcellijuryndregulategutmicrobiotadisturbancesriptolidealsoosesssanti-infaatory andimmunomodulatoryproperties，suppressesmesangialcellproliferation，andprotectspodocytes.Celastroldemonstratesntiinflammatoryandimmunomodulatoryfunctionsaswellastheabilitytoimproveendothelialcelldamage.Throughthese mechanisms，T.wilfordiianditsactivecomponentscanplayaroleinalleviatingclinicalsymptomsanddelayingdiseaseprogresion inthetreatment of IgAN.Futureresearch shouldfocusonin-depthanalysisand mechanisticinvestigationof theseactive ingredients，promotehigh-qualityclinical studies，systematicallevaluatethesynergisticeffectsamongthem，andemphasize strategiesforreducing toxicityandenhancingeficacy，therebyprovidingmorecomprehensiveandreliableevidence-based foundations for the clinical treatment of IgAN.

KEYWORDS Tripterygium wilfordii；immunoglobulin Anephropathy；active ingredients；mechanismof action

免疫球蛋白A肾病（immunoglobulinAnephropathy，IgAN）是一种全球范围内常见的原发性肾小球肾炎，以反复发作、血尿、蛋白尿等为主要临床表现，以肾小球系膜区免疫球蛋白A（immunoglobulinA，IgA）沉积为主要病理特征。（剩余10501字）