原发性胆汁性胆管炎25-（OH）维生素D、AMA-M2、ALP、IgM相关性研究

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[关键词] 原发性胆汁性胆管炎;25-（OH）维生素D;AMA-M2;ALP;IgM

[中图分类号] R446.6          [文献标识码] B          [文章编号] 1673-9701（2021）15-0125-04

Study on the correlation between primary biliary cholangitis and 25-（OH）vitamin D， AMA-M2，ALP，IgM

DAI Wei LI Shiyun   LIN Ye   SONG Liyun   ZHONG Jianshen

Department of Laboratory Medicine， Ganzhou People′s Hospital in Jiangxi Province， Ganzhou 341000， China

[Abstract] Objective To analyze the relationship between primary biliary cholangitis and 25-（OH）vitamin D， antimitochondrial antibody M2（AMA-M2）， alkaline phosphatase （ALP）， immunity globulin M （IgM）. Methods A total of 28 patients with primary biliary cholangitis （group A）， 20 patients with liver cirrhosis（group B）， and 20 physical examinations （group C） in our hospital From January 2018 to December 2019 were collected for research. Anti-mitochondrial antibodies，25-（OH） vitamin D， IgM， and ALP were tested. The results were compared and analyzed. Results ①The positive rate of AMA and AMA-M2 in group A was higher than that in group B， and the difference was statistically significant（P<0.05）. ②The 25-（OH） vitamin D， IgM， and ALP levels of the three groups were significantly different， and the differences were statistically significant（P<0.05）. There was significant difference in the AST levels between group A and group B （P<0.05）. Conclusion There is a close relationship between primary biliary cholangitis and 25-（OH） vitamin D， AMA-M2， ALP and IgM. Combined detection is better than single index detection. The former can better fight for early diagnosis and treatment in the clinic，provide new ideas and scientific basis，and it is recommended for clinical promotion and application.

[Key words] Primary biliary cholangitis; 25-（OH）vitamin D; AMA-M2; ALP; IgM

原發性胆汁性胆管炎（Primary biliary cholangitis，PBC）的特点是免疫介导的肝内胆小管和门静脉的炎症破坏，可进一步导致肝纤维化和肝衰竭。（剩余6969字）

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