钛合金梯度锶掺杂ZIF-8膜层的合成及抗菌性能研究

打开文本图片集

文章编号：2096-2983（2025）05-0013-09

引文格式：，等．钛合金梯度锶掺杂 ZIF-8膜层的合成及抗菌性能研究[J]．有色金属材料与工程，2025， 46（5）： 13-21.DOI：10.13258/j.cnki.nmme.20250325001.DAI Xinrui， ZHAO Jianghui， QI Shengcai， etal.Synthesis and antibacterial performance of gradient ZIF-8films doped withstrontiumontitanium aloy[J].NonferrousMetal Materials and Engineering，2025， 46（5） ： 13-21.

关键词：水热法；ZIF-8膜层；锶掺杂；耐腐蚀性；抗菌能力中图分类号：R318.08 文献标志码：A

Synthesis and antibacterial performance of gradient ZIF-8 films doped with strontium on titanium alloy

DAI Xinrui1， ZHAO Jianghui1， Ql Shengcai2，3， LIWei1， LIU Xinkuan1， CHEN Xiaohong1， ZHANG Ke¹，MA Fengcang1 （1.SchoolofMaterialsand Chemistry，Universityof Shanghai for Science andTechnology，Shanghai 2ooo93，China; 2.DepartmentofProsthodontics，ShanghaiStomatological Hospital，Fudan University，Shanghai 2Oo31，China; 3. Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases， Fudan University， Shanghai 200032， China）

Abstract： In order to endow titanium alloys with osteogenic and antibacterial properties， TiO2 nanorods （TN） films were prepared on the surface of pure titanium using a hydrothermal method， then various strontium-doped ZIF-8 （Sr-ZIF-8） coatings were synthesized. TN/Sr-ZIF-8 composite films were fabricated using these above two processes. The study found that the doping concentration of strontium affected the morphology of ZIF-8， but not its phase composition. Electrochemical test results showed that the strontium doping improved the corrosion resistance of the film in simulated body fluid.Metal ions could be released over a long period in simulated body fluid， and the release rate varied under different pH conditions， indicating the pH responsiveness of ZIF-8. In vitro mineralization experiments demonstrated that the ability of the film to induce hydroxyapatite formation was positively correlated with the strontium doping concentration. Furthermore， in vitro antibacterial tests showed that ZIF-8 exhibited antimicrobial activity against both Escherichia coli and Staphylococcus aureus， with inhibition rates of 72.4% and 48.3% ，respectively.

Keywords： hydrothermal method; ZIF-8； strontium; corrosion resistance; antibacterial ability

金属具有较高的机械强度，常被用作人体硬组织替代或修复用材料，近年来金属生物材料的研发引起了广泛的关注[1]。（剩余11814字）