光动力联合免疫检查点抑制剂治疗恶性肿瘤的研究进展

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中图分类号：R318.51 文献标志码：A 文章编号：0253-2395（2025）04-0815-14

Abstract：Malignant tumorsareseriouslyharmful tohumanhealth.Photodynamic therapyisanemerging therapywithadvantagesof lowtrauma，lowsideefectsandhighspatiotemporalcontrol.Ithasbeenwidelyusedintheclinical treatmentofmalignanttumors， butitislimitedtotetreamentoflocaltumorsFordistantmetastatictumoursorlsions tatcanotbepreciselylocated，hotody namictherapyasertailitatis.munothrapyspeciallmmuneckpointitors，asrought tetreatmntoflig nanttumors intoanewera.However，thelowexpressonlevelofimmunecheckpointintumorcelsanditsinsuffcientactivationof the host mmunesystemconstitute majorobstacles.Photodynamic therapycan activate the immune functionof the bodyand improve thetumor microenvironment， which provides apossibiltyforthe combinationof photodynamic therapyand immunotherapy. Nanoparticlescansimultaneouslyloadphotosensitizersandimmunecheckpointinhibitorstoachievecombinedtherapeuticeffect andimprovedrug targeting.Inthispaper，theexperimentalresearchonthecombinationofphotodynamicandimmunecheckpointinhibitors using nanotechnologyinthetreatmentofmalignanttumors isreviewed.Anditsclinicalapplicationis prospected.

KeyWords： photodynamic therapy; PD-1/PD-L1; CTLA-4; combination therapy; nano drug-carryingparticles

0 引言

恶性肿瘤一直是危害人体健康和生命的“罪魁祸首”，其发病率1逐年上升，因此寻找高效的治疗方法成为人们孜孜不倦探索的动力。（剩余37959字）