PD-L1在乳腺癌中表达及临床意义

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【摘要】目的：探究乳腺癌患者PD-L1表达及临床意义。方法：选择在我院进行乳腺癌筛查的女性患者作为研究对象（时间2017年1月—2019年6月），原位癌15例、浸润癌35例、良性病变15例，对患者进行免疫组织化学染色，比较患者PD-L1阳性表达情况。结果：35例浸润癌患者PD-L1阳性表达率57.14%（20/35），高于15例原位癌患者PD-L1阳性表达率26.67%（4/15），差异显著（P

【关键词】乳腺癌；PD-L1；阳性表达率

PD-L1 expression in breast cancer and its clinical significance

ZHANG Meifang， WU Dongen， HU Leilei， CHEN Zhifei

Department of Pathology，Maternal and Child Health Hospital of Heyuan City， Heyuan， Guangdong 517000， China

【Abstract】Objective：To explore the expression and clinical significance of PD-L1 in breast cancer patients.Methods：Selected female patients undergoing breast cancer screening in our hospital as the research object （time from January 2017 to June 2019），15 cases of carcinoma in situ，35 cases of invasive carcinoma，and 15 cases of benign lesions.The patients were examined by immunohistochemical staining to compare the positive expression of PD-L1 in patients.Results：The positive expression rate of PD-L1 in 35 patients with invasive carcinoma was 57.14%（20/35），which was higher than 26.67%（4/15）in 15 patients with carcinoma in situ，the difference was significant（P

【Key Words】Breast cancer； PD-L1； Positive expression rate

“乳腺癌”多发于外上象限乳房，是由于乳腺上皮细胞增殖失控引起的恶变，在女性恶性肿瘤中发病率最高，病因尚未完全清楚，存在遗传风险。（剩余5718字）