基于临床生物信息学的白藜芦醇对自闭症谱系障碍的潜在治疗意义

打开文本图片集

Potential therapeutic significance of resveratrol for autism spectrum disorders based on clinical bioinformatics

LYU Yanhua， ZHONG Xiaoyun， WANG Kanglong， ZHAO Hongxia， YU Qi

School of Management， Shanxi Medical University， Shanxi 030600 China

*Corresponding Author  LYU Yanhua， E⁃mail：lvyanhua01@163.com

Abstract  Objective：To explore the potential therapeutic effect of resveratrol on autism spectrum disorders （ASD） based on clinical bioinformatics.Methods：Obtain whole genome expression profiles of resveratrol and ASD from GEO database； Perform differentially expressed gene analysis， Gene Ontology enrichment analysis， Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis， and protein-protein interaction network analysis on the whole genome expression profile data of resveratrol and ASD，and screen for core genes；Using domain knowledge scoring method to validate the effectiveness of core genes with important regulatory effects on resveratrol in Chinese and English databases.Results：294 and 256 differentially expressed genes（DEGs） were identified in the resveratrol group and ASD group， respectively；The genes enriched in the resveratrol group GO are mainly related to nervous system development， neurogenesis， synaptic tissue， etc. The KEGG pathway enrichment is mainly related to animal mitochondrial autophagy，cholesterol metabolism，thyroid hormone synthesis， etc； The enrichment of KEGG pathway in ASD group is mainly related to mitogen activated protein kinase signaling pathway， thyroid hormone synthesis， oxytocin signaling pathway，etc；A total of 11 core genes were identified in the PPI network of resveratrol group DEGs， mainly related to cell cycle， synaptogenesis and synaptic plasticity， inflammation， and immune response，etc.Conclusions：Resveratrol has functions such as inhibiting inflammatory response， promoting immune regulation， improving oxidative stress， regulating synaptogenesis and synaptogenesis processes， and regulating neurotransmitter release. It has potential therapeutic significance for ASD.

Keywords    resveratrol； autism spectrum disorders； differentially expressed gene analysis； enrichment analysis； protein-protein interaction network； domain knowledge score； clinical bioinformatics

摘要  目的：基于临床生物信息学探讨白藜芦醇对自闭症谱系障碍（ASD）的潜在治疗作用。（剩余14075字）