吸入麻醉药对肾脏缺血再灌注损伤的保护作用

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中图分类号：R699.2 文献标志码：A 文章编号：1001-5779（2025）08-0801-08

DOI：10.3969/j.issn. 1001-5779.2025.08.013

Abstract：Renal ischemia-reperfusion injury（IRI） is the maincause of acute kidneyinjury（AKI），oftenoccurringduring critical surgeries such as transplantation，largevessel surgery，liversurgery，and heart surgery.Inrecent years，many studieshavefoundthatinhalationanestheticscanallviaterenalIRIandmayhavegoodprospectsforperioperative protectionofrenalfunction.The protectiveefectof inhalation anestheticson the kidneys mayberelatedtothe timing， concentration，andtimewindowof treatment.Antioxidative，anti-inflammatoryandanti-apoptoticefectsbyactivating multiple signaling pathways inthe kidney，regulating gene expressionand immunoregulation may be the main mechanism bywhichinhalationanestheticsimproverenal IRI.Thisarticleprovidesareviewofexperimentalandclinical studieson theuseof inhalationanesthetics toaleviaterenal IRIandprotectrenal function，aswell astheirmechanismsof action， based onrecent domesticand international research literature.The aim is to provide reference for perioperative renal function protection.

Keywords：Inhalation anesthetics；Ischemia-reperfusioninjury；Renal function

肾脏缺血再灌注损伤（Ischemia-reperfusioninjury，IRI）作为急性肾损伤（Acutekidney injury，AKI的主要致病因素之一，常见于心脏、大血管、肝脏等手术后的并发症中，且与术后患者的死亡率密切相关。（剩余19026字）