内质网应激信号通路在骨质疏松症中的研究进展

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中图分类号：R681 文献标志码：A 文章编号：1001-5779（2025）08-0795-06

DOI：10.3969/j. issn.1001-5779.2025.08.012

Abstract：Osteoporosis（OP）isamultifactorial systemic skeletaldisease characterized primarilybyclinical symptoms such as bone pain，muscle weakness，fractures，and limited mobility.The disruption of the balance between bone resorptionandboneremodelingisanimportantaspectof thepathologicalmechanismofOP.Endoplasmicreticulumstress （ERS），as a self-defense response，is a means by which cells cope with the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum and disturbances in calcium ions.An increasing numberof studies have confirmed thatERSplaysakeyroleinthepathologicalmechanismsofOP，butthespecificmechanismsremainunclear.Thisarticle reviews the pathological mechanisms ofOP，theconnection between ERS andOP，and the potential value of targeting ERS for the treatment of OP，with the goal of providing insights for the prevention and treatment of OP.

KeyWords：Endoplasmic reticulum stress；Osteoporosis；Osteoblasts；Osteoclasts

骨质疏松症（Osteoporosis，OP）是一种与年龄相关的慢性骨重塑疾病，临床上较为常见。（剩余13316字）