ICIs时代晚期肾细胞癌幸存者的后续原发性癌症谱分析

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Abstract：To assess the risk characteristics and influencing factors of subsequent primary cancers （SPCs） in survivors of advanced renalcellcarcinoma（RCC） in the era of immune checkpoint inhibitors （ICIs）（November 2015-December 2O21），standardized incidence ratios （ （RSi ）and excess risks were calculated based on the SEER database，and 873 patients with advanced RCC were included. Analysis was performed stratified by gender and period before and after the COVID-19 epidemic.The results showed that patients with advanced RCC faced 50% higher solid tumors risks （ ，and excess risks were 63.89 people per 10 0o0 people in every year. The risks were higher in the female urinary system （bladder， RSi=2，39 in women， RSi=1.56 in men） and respiratory system （lung and bronchial cancer， RSi=1.57 in women， RSi=1.11 in men），however， the risks of the thyroid gland in males were higher （ RSi=6.17 in men， RSi=5，41 in women）.After the epidemic，lung and bronchial cancers decreased significantly （ RSi=1.12 ， P>0.05 ），indicating delayed diagnosis，while thyroid cancer remained at high risk（ ΔRSi=4.Δ58Ω 》：

Keywords：renal cell carcinoma；subsequent primary cancer；immune checkpoint inhibitor；standardized incidence rate

肾细胞癌（RCC）作为泌尿生殖系统最常见的癌症，占所有新发癌症病例的 3.7%[1-2] ，截至2021年美国有13 780人患该类癌症死亡[3]。（剩余19981字）