氧化透明质酸交联碳酰肤明胶/半胱氨酸壳聚糖复合水凝胶的制备及pH响应和抗氧化性能

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中图分类号：O636.1 文献标志码：A 文章编号： 1000-5013（2025）06-0660-06

Preparation of Oxidized Hyaluronic Acid Crosslinked Carbohydrazide-Gelatin/Cysteine-Chitosan Composite Hydrogel With pH-Responsive and Antioxidant Properties

YU Ying 1，2 ， PENG Yonggang 1，2 ， LI Mingchun 1，2 ，XIN Meihua 1，2

（1.College of Materials Science and Engineering，Huaqiao University，Xiamen 36lo21，China; 2.Engineering Research Center of Environment-Friendly Functional Materials，Ministry of Education， Huaqiao University，Xiamen 36l021，China）

Abstract：To enhance the biological functionality of natural polymer hydrogels，a pH-responsive composite hydrogel was designed and constructed based on oxidized hyaluronic acid（OHA），cysteine-grafted chitosan （CSCys），and carbonyl hydrazide-modified gelatin（Gel-CDH）.The hydrogel achieved dynamic covalent crosslinking through Schiff base reactions between aldehyde groups and amino/hydrazide groups to form a stable and tunable thre-dimensional network structure. By adjusting the OHA ratio，three types of hydrogels were prepared，and their swelling behavior in relation to pH values as well as antioxidant activity were systematically evaluated. The results showed that this composite hydrogel not only exhibited excellnt pH responsivenessbut also demonstrated superior free radical scavenging capability due to the synergistic effects offunctional groups such as thiol groups.

Keywords：hydrogel；chitosan；pH-responsive；antioxidan

随着组织工程、创面愈合及生物医用材料的发展，天然高分子基水凝胶因其优良的生物相容性、可降解性及类细胞外基质（ECM）的三维结构而受到广泛关注[1-2]。（剩余9691字）